Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats

	Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
	Ji, Weifeng 1; Huang, Haiying 2; Chao, Ji 3; Lu, Wuchao 1; Guo, Jianyou4
摘要	Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-alpha. and IL-1 beta. level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy.
	2014
语种	英语
发表期刊	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1741-427X
卷号	2014 期号:0 页码:679259
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000330444000001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14140
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Med Univ, Dept Orthoped, Chinese Orthoped & Traumatol Res Inst, Affiliated Hosp Zhejiang 1, Hangzhou 310006, Zhejiang, Peoples R China 2.Henan Univ Tradit Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China 3.Fujian Med Univ, Sch Basic Med, Fuzhou 350108, Peoples R China 4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Ji, Weifeng,Huang, Haiying,Chao, Ji,et al. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):679259.
APA	Ji, Weifeng,Huang, Haiying,Chao, Ji,Lu, Wuchao,&Guo, Jianyou.(2014).Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),679259.
MLA	Ji, Weifeng,et al."Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):679259.

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