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Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
Ji, Weifeng1; Huang, Haiying2; Chao, Ji3; Lu, Wuchao1; Guo, Jianyou4
2014
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
文章类型Article
卷号2014期号:0页码:679259
摘要Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-alpha. and IL-1 beta. level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy.
收录类别SCI
语种英语
WOS记录号WOS:000330444000001
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14140
专题中国科学院心理健康重点实验室
作者单位1.Chinese Med Univ, Dept Orthoped, Chinese Orthoped & Traumatol Res Inst, Affiliated Hosp Zhejiang 1, Hangzhou 310006, Zhejiang, Peoples R China
2.Henan Univ Tradit Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China
3.Fujian Med Univ, Sch Basic Med, Fuzhou 350108, Peoples R China
4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China
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Ji, Weifeng,Huang, Haiying,Chao, Ji,et al. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):679259.
APA Ji, Weifeng,Huang, Haiying,Chao, Ji,Lu, Wuchao,&Guo, Jianyou.(2014).Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),679259.
MLA Ji, Weifeng,et al."Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):679259.
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