PSYCH OpenIR  > 中国科学院心理健康重点实验室
High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response
Wang, Hongbo1,2; Xing, Xiaoli1,2; Liang, Jing1; Bai, Yunjing1; Lui, Zhengkui1; Zheng, Xigeng1
2014-09-01
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
文章类型Article
卷号124期号:0页码:188-195
摘要Exposure therapy is widely used to treat anxiety disorders, including posttraumatic stress disorder (PTSD). However, preventing the return of fear is still a major challenge after this behavioral treatment. An increasing number of studies suggest that high-dose glucocorticoid treatment immediately after trauma can alleviate the symptoms of PTSD in humans. Unknown is whether high-dose glucocorticoid treatment following fear conditioning suppresses the return of fear. In the present study, a typical fear renewal paradigm (AAB) was used, in which the fear response to an auditory cue can be restored in a novel context (context B) when both training and extinction occur in the same context (context A). We trained rats for auditory fear conditioning and administered corticosterone (CORT; 5 and 25 mg/kg, i.p.) or vehicle with different delays (1 and 24 h). Forty-eight hours after drug injection, extinction was conducted with no drug in the training context, followed by a test of tone-induced freezing behavior in the same (AAA) or a shifted (AAB) context. Both immediate and delayed administration of high-dose CORT after fear conditioning reduced fear renewal. To examine the anxiolytic effect of CORT, independent rats were trained for cued or contextual fear conditioning, followed by an injection of CORT (5 and 25 mg/kg, i.p.) or vehicle at a 1 or 24 h delay. One week later, anxiety-like behavior was assessed in the elevated plus maze (EPM) before and after fear expression. We found that high-dose CORT decreased anxiety-like behavior without changing tone- or context-induced freezing. These findings indicate that a single high-dose CORT administration given after fear conditioning may selectively suppress fear renewal by reducing anxiety-like behavior and not by altering the consolidation, retrieval, or extinction of fear memory. (C) 2014 Elsevier Inc All rights reserved.
关键词Corticosterone Fear Conditioning Fear Renewal Anxiety Elevated Plus-maze
收录类别SCI
语种英语
WOS记录号WOS:000343621900027
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14142
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Hongbo,Xing, Xiaoli,Liang, Jing,et al. High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,124(0):188-195.
APA Wang, Hongbo,Xing, Xiaoli,Liang, Jing,Bai, Yunjing,Lui, Zhengkui,&Zheng, Xigeng.(2014).High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,124(0),188-195.
MLA Wang, Hongbo,et al."High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124.0(2014):188-195.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000343621900027.(1130KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Hongbo]的文章
[Xing, Xiaoli]的文章
[Liang, Jing]的文章
百度学术
百度学术中相似的文章
[Wang, Hongbo]的文章
[Xing, Xiaoli]的文章
[Liang, Jing]的文章
必应学术
必应学术中相似的文章
[Wang, Hongbo]的文章
[Xing, Xiaoli]的文章
[Liang, Jing]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。