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High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response
Wang, Hongbo1,2; Xing, Xiaoli1,2; Liang, Jing1; Bai, Yunjing1; Lui, Zhengkui1; Zheng, Xigeng1
2014-09-01
Source PublicationPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
SubtypeArticle
Volume124Issue:0Pages:188-195
AbstractExposure therapy is widely used to treat anxiety disorders, including posttraumatic stress disorder (PTSD). However, preventing the return of fear is still a major challenge after this behavioral treatment. An increasing number of studies suggest that high-dose glucocorticoid treatment immediately after trauma can alleviate the symptoms of PTSD in humans. Unknown is whether high-dose glucocorticoid treatment following fear conditioning suppresses the return of fear. In the present study, a typical fear renewal paradigm (AAB) was used, in which the fear response to an auditory cue can be restored in a novel context (context B) when both training and extinction occur in the same context (context A). We trained rats for auditory fear conditioning and administered corticosterone (CORT; 5 and 25 mg/kg, i.p.) or vehicle with different delays (1 and 24 h). Forty-eight hours after drug injection, extinction was conducted with no drug in the training context, followed by a test of tone-induced freezing behavior in the same (AAA) or a shifted (AAB) context. Both immediate and delayed administration of high-dose CORT after fear conditioning reduced fear renewal. To examine the anxiolytic effect of CORT, independent rats were trained for cued or contextual fear conditioning, followed by an injection of CORT (5 and 25 mg/kg, i.p.) or vehicle at a 1 or 24 h delay. One week later, anxiety-like behavior was assessed in the elevated plus maze (EPM) before and after fear expression. We found that high-dose CORT decreased anxiety-like behavior without changing tone- or context-induced freezing. These findings indicate that a single high-dose CORT administration given after fear conditioning may selectively suppress fear renewal by reducing anxiety-like behavior and not by altering the consolidation, retrieval, or extinction of fear memory. (C) 2014 Elsevier Inc All rights reserved.
KeywordCorticosterone Fear Conditioning Fear Renewal Anxiety Elevated Plus-maze
Indexed BySCI
Language英语
WOS IDWOS:000343621900027
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14142
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Hongbo,Xing, Xiaoli,Liang, Jing,et al. High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,124(0):188-195.
APA Wang, Hongbo,Xing, Xiaoli,Liang, Jing,Bai, Yunjing,Lui, Zhengkui,&Zheng, Xigeng.(2014).High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,124(0),188-195.
MLA Wang, Hongbo,et al."High-dose corticosterone after fear conditioning selectively suppresses fear renewal by reducing anxiety-like response".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124.0(2014):188-195.
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