Institutional Repository of Key Laboratory of Mental Health, CAS
| Different topological organization of human brain functional networks with eyes open versus eyes closed | |
Xu, Pengfei1; Huang, Ruiwang1,2; Wang, Jinhui1; Van Dam, Nicholas T.3; Xie, Teng1; Dong, Zhangye1; Chen, Chunping4 ; Gu, Ruolei5; Zang, Yu-Feng1,6; He, Yong1,7; Fan, Jin8,9,10,11; Luo, Yue-Jia12
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| 摘要 | Opening and closing the eyes are fundamental behaviors for directing attention to the external versus internal world. However, it remains unclear whether the states of eyes-open (EO) relative to eyes-closed (EC) are associated with different topological organizations of functional neural networks for exteroceptive and interoceptive processing (processing the external world and internal state, respectively). Here, we used resting-state functional magnetic resonance imaging and neural network analysis to investigate the topological properties of functional networks of the human brain when the eyes were open versus closed. The brain networks exhibited higher cliquishness and local efficiency, but lower global efficiency during the EO state compared to the EC state. These properties suggest an increase in specialized information processing along with a decrease in integrated information processing in EO (vs. EC). More importantly, the "exteroceptive" network, including the attentional system (e.g., superior parietal gyrus and inferior parietal lobule), ocular motor system (e.g., precentral gyrus and superior frontal gyrus), and arousal system (e.g., insula and thalamus), showed higher regional nodal properties (nodal degree, efficiency and betweenness centrality) in EO relative to EC. In contrast, the "interoceptive" network, composed of visual system (e.g., lingual gyrus, fusiform gyrus and cuneus), auditory system (e.g., Heschl's gyurs), somatosensory system (e.g., postcentral gyrus), and part of the default mode network (e.g., angular gyrus and anterior cingulate gyrus), showed significantly higher regional properties in EC vs. EO. In addition, the connections across sensory modalities were altered by volitional eye opening. The synchronicity between the visual system and the motor, somatosensory and auditory systems, characteristic of EC, was attenuated in EO. Further, the connections between the visual system and the attention, arousal and subcortical systems were increased in EO. These results may indicate that EO leads to a suppression of sensory modalities (other than visual) to allocate resources to exteroceptive processing. Our findings suggest that the topological organization of human brain networks dynamically switches corresponding to the information processing modes as we open or close our eyes. (C) 2014 Published by Elsevier Inc. |
| 关键词 | Exteroceptive Interoceptive Connectome Graph theory Resting-state functional MRI |
| 2014-04-15 | |
| 语种 | 英语 |
| 发表期刊 | NEUROIMAGE
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| ISSN | 1053-8119 |
| 卷号 | 90期号:0页码:246-255 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000338909500025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/14150 |
| 专题 | 中国科学院心理健康重点实验室 |
| 作者单位 | 1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.S China Normal Univ, Sch Psychol, Ctr Studies Psychol Applicat,Brain Imaging Ctr, Guangdong Key Lab Mental Hlth & Cognit Sci, Guangzhou 510631, Guangdong, Peoples R China 3.NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 6.Hangzhou Normal Univ, Affiliated Hosp, Ctr Cognit & Brain Disorders, Hangzhou 310015, Zhejiang, Peoples R China 7.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China 8.CUNY, Queens Coll, Dept Psychol, New York, NY 11367 USA 9.Ichan Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA 10.Ichan Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA 11.Ichan Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA 12.Shenzhen Univ, Inst Affect & Social Neurosci, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Pengfei,Huang, Ruiwang,Wang, Jinhui,et al. Different topological organization of human brain functional networks with eyes open versus eyes closed[J]. NEUROIMAGE,2014,90(0):246-255. |
| APA | Xu, Pengfei.,Huang, Ruiwang.,Wang, Jinhui.,Van Dam, Nicholas T..,Xie, Teng.,...&Luo, Yue-Jia.(2014).Different topological organization of human brain functional networks with eyes open versus eyes closed.NEUROIMAGE,90(0),246-255. |
| MLA | Xu, Pengfei,et al."Different topological organization of human brain functional networks with eyes open versus eyes closed".NEUROIMAGE 90.0(2014):246-255. |
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