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Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants
Levran, Orna1; Peles, Einat2,3; Randesi, Matthew1; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1
2014
Source PublicationPHARMACOGENOMICS
ISSN1462-2416
SubtypeArticle
Volume15Issue:16Pages:2001-2009
AbstractBackground & aim: The dopaminergic pathways have been implicated in the etiology of drug addictions. The aim of this study was to determine if variants in dopaminergic genes are associated with heroin addiction. Materials & methods: The study includes 828 former heroin addicts and 232 healthy controls, of predominantly European ancestry. Ninety seven SNPs (13 genes) were analyzed. Results: Nine nominally significant associations were observed at CSNK1E, ANKK1, DRD2 and DRD3. Conclusion: The results support our previous report of association of CSNK1E SNP rs1534891 with protection from heroin addiction. CSNK1E interacts with circadian rhythms and DARPP-32 and has been implicated in negative regulation of sensitivity to opioids in rodents. It may be a target for drug addiction treatment.
Keywordcasein kinase 1 epsilon circadian rhythms dopaminergic reward pathways heroin addiction SNP rs1534891
Indexed BySCI
Language英语
WOS IDWOS:000346486500006
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14166
Collection健康与遗传心理学研究室
Affiliation1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel
3.Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
7.VA New York Harbor Healthcare Syst, New York, NY 10010 USA
8.NYU, Sch Med, New York, NY 10010 USA
9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA
Recommended Citation
GB/T 7714
Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants[J]. PHARMACOGENOMICS,2014,15(16):2001-2009.
APA Levran, Orna.,Peles, Einat.,Randesi, Matthew.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2014).Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants.PHARMACOGENOMICS,15(16),2001-2009.
MLA Levran, Orna,et al."Dopaminergic pathway polymorphisms and heroin addiction: further support for association of CSNK1E variants".PHARMACOGENOMICS 15.16(2014):2001-2009.
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