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Changes in structural and functional connectivity among resting-state networks across the human lifespan
Betzel, Richard F.1; Byrge, Lisa1; He, Ye2; Goni, Joaquin1; Zuo, Xi-Nian2; Sporns, Olaf1
2014-11-15
Source PublicationNEUROIMAGE
ISSN1053-8119
SubtypeArticle
Volume102Issue:2Pages:345-357
AbstractAt rest, the brain's sensorimotor and higher cognitive systems engage in organized patterns of correlated activity forming resting-state networks. An important empirical question is how functional connectivity and structural connectivity within and between resting-state networks change with age. In this study we use network modeling techniques to identify significant changes in network organization across the human lifespan. The results of this study demonstrate that whole-brain functional and structural connectivity both exhibit reorganization with age. On average, functional connections within resting-state networks weaken in magnitude while connections between resting-state networks tend to increase. These changes can be localized to a small subset of functional connections that exhibit systematic changes across the lifespan. Collectively, changes in functional connectivity are also manifest at a system-wide level, as components of the control, default mode, saliency/ventral attention, dorsal attention, and visual networks become less functionally cohesive, as evidenced by decreased component modularity. Paralleling this functional reorganization is a decrease in the density and weight of anatomical white-matter connections. Hub regions are particularly affected by these changes, and the capacity of those regions to communicate with other regions exhibits a lifelong pattern of decline. Finally, the relationship between functional connectivity and structural connectivity also appears to change with age; functional connectivity along multi-step structural paths tends to be stronger in older subjects than in younger subjects. Overall, our analysis points to age-related changes in inter-regional communication unfolding within and between resting-state networks. (c) 2014 Elsevier Inc. All rights reserved.
KeywordConnectome Functional Connectivity Lifespan Modularity
Indexed BySCI
Language英语
WOS IDWOS:000345391700010
Citation statistics
Cited Times:205[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14167
Collection中国科学院行为科学重点实验室
Affiliation1.Indiana Univ, Bloomington, IN 47405 USA
2.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci & Magnet Resonance Imaging Res, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Betzel, Richard F.,Byrge, Lisa,He, Ye,et al. Changes in structural and functional connectivity among resting-state networks across the human lifespan[J]. NEUROIMAGE,2014,102(2):345-357.
APA Betzel, Richard F.,Byrge, Lisa,He, Ye,Goni, Joaquin,Zuo, Xi-Nian,&Sporns, Olaf.(2014).Changes in structural and functional connectivity among resting-state networks across the human lifespan.NEUROIMAGE,102(2),345-357.
MLA Betzel, Richard F.,et al."Changes in structural and functional connectivity among resting-state networks across the human lifespan".NEUROIMAGE 102.2(2014):345-357.
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