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The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels
Shi, Shu-Ning1; Shi, Jin-Li1; Liu, Yong1; Wang, Yan-Li1; Wang, Chun-Guo1; Hou, Wen-Hui1; Guo, Jian-You2
2014
发表期刊EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
文章类型Article
卷号2014期号:0页码:325948
摘要Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was to investigate the anxiolytic effects of valtrate in rats. The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM). Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA). The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT. Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum. Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis.
收录类别SCI
语种英语
WOS记录号WOS:000333630900001
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14172
专题中国科学院心理健康重点实验室
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
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Shi, Shu-Ning,Shi, Jin-Li,Liu, Yong,et al. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):325948.
APA Shi, Shu-Ning.,Shi, Jin-Li.,Liu, Yong.,Wang, Yan-Li.,Wang, Chun-Guo.,...&Guo, Jian-You.(2014).The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),325948.
MLA Shi, Shu-Ning,et al."The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):325948.
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