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The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels
Shi, Shu-Ning1; Shi, Jin-Li1; Liu, Yong1; Wang, Yan-Li1; Wang, Chun-Guo1; Hou, Wen-Hui1; Guo, Jian-You2
2014
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
SubtypeArticle
Volume2014Issue:0Pages:325948
AbstractValtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was to investigate the anxiolytic effects of valtrate in rats. The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM). Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA). The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT. Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum. Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis.
Indexed BySCI
Language英语
WOS IDWOS:000333630900001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14172
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Shi, Shu-Ning,Shi, Jin-Li,Liu, Yong,et al. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):325948.
APA Shi, Shu-Ning.,Shi, Jin-Li.,Liu, Yong.,Wang, Yan-Li.,Wang, Chun-Guo.,...&Guo, Jian-You.(2014).The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),325948.
MLA Shi, Shu-Ning,et al."The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):325948.
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