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| The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels | |
Shi, Shu-Ning1; Shi, Jin-Li1; Liu, Yong1; Wang, Yan-Li1; Wang, Chun-Guo1; Hou, Wen-Hui1; Guo, Jian-You2
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| 摘要 | Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which is a Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was to investigate the anxiolytic effects of valtrate in rats. The animals were orally administered valtrate (5, 10, and 20 g/kg daily) for 10 days and exposed to open field test (OFT) and elevated plus-maze (EPM). Then the corticosterone levels in the rat serum were measured by enzyme-linked immunosorbent assay (ELISA). The valtrate (10 mg/kg, p.o.) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the EPM and the number of central entries in the OFT. Valtrate (10 mg/kg, p.o.) significantly reduced the corticosterone level in the rat serum. Taken together, these results suggest that the valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis. |
| 2014 | |
| 语种 | 英语 |
| 发表期刊 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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| ISSN | 1741-427X |
| 卷号 | 2014期号:0页码:325948 |
| 期刊论文类型 | Article |
| 收录类别 | SCI |
| WOS记录号 | WOS:000333630900001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.psych.ac.cn/handle/311026/14172 |
| 专题 | 中国科学院心理健康重点实验室 |
| 作者单位 | 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Shu-Ning,Shi, Jin-Li,Liu, Yong,et al. The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):325948. |
| APA | Shi, Shu-Ning.,Shi, Jin-Li.,Liu, Yong.,Wang, Yan-Li.,Wang, Chun-Guo.,...&Guo, Jian-You.(2014).The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),325948. |
| MLA | Shi, Shu-Ning,et al."The Anxiolytic Effects of Valtrate in Rats Involves Changes of Corticosterone Levels".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):325948. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| WOS_000333630900001.（1736KB） | 期刊论文 | 出版稿 | 暂不开放 | CC BY-NC-SA | 请求全文 | |
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