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Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia
Zhou, Yuan1,2; Wang, Zheng3; Zuo, Xi-Nian1,2; Zhang, Huiran3; Wang, Yun1; Jiang, Tianzi4,5; Liu, Zhening3
2014-10-01
Source PublicationSCHIZOPHRENIA RESEARCH
ISSN0920-9964
SubtypeArticle
Volume159Issue:1Pages:80-89
AbstractWorking memory (WM) deficit is an important component of impaired cognition in schizophrenia. However, between-studies inconsistencies as to the specific functional substrate imply that inter-individual variability (IIV) in the WM performance is associated with IIV in brain activity in schizophrenia. To examine the neural substrate of this WM IIV, we studied whether the neural mechanisms that underlie individual differences in WM capacity are the same in schizophrenia patients and healthy people. We correlated the IIV of the task-evoked brain activity and task performance during an n-back WM task with the IIV of the moment-to-moment variability in intrinsic resting-state activity, as measured by the amplitude of low-frequency fluctuations (ALFFs) and further compared this relationship between 17 patients with first-episode schizophrenia (FES) and 18 healthy controls. Between-group comparisons of the correlation patterns indicated aberrant ALFF-WM activation correlations and ALFF-WM performance correlations in the FES patients, but no significant changes were detected in any single measurement of these three characteristics. Specifically, we found increased positive ALFF-WM activation correlations in the bilateral lateral prefrontal cortices, posterior parietal cortices and fusiform gyri in the FES patients. We also observed significant increases in positive ALFF-WM performance correlations in the bilateral ventromedial prefrontal cortices in the FES patients. This hyper-coupling between the ALFF and fMRI measures during a WM task may indicate that it was difficult for the patients to detach themselves from one state to transition to another and suggests that the inefficient cortical function in schizophrenia stems from the intrinsic functional architecture of the brain. (C) 2014 Elsevier B. V. All rights reserved.
KeywordFirst-episode Schizophrenia Amplitude Of Low-frequency Fluctuation Working Memory Task-evoked Activity Prefrontal Cortex Brain-behavior Association
Indexed BySSCI
Language英语
WOS IDWOS:000343107400014
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14183
Collection中国科学院行为科学重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
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Zhou, Yuan,Wang, Zheng,Zuo, Xi-Nian,et al. Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2014,159(1):80-89.
APA Zhou, Yuan.,Wang, Zheng.,Zuo, Xi-Nian.,Zhang, Huiran.,Wang, Yun.,...&Liu, Zhening.(2014).Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia.SCHIZOPHRENIA RESEARCH,159(1),80-89.
MLA Zhou, Yuan,et al."Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia".SCHIZOPHRENIA RESEARCH 159.1(2014):80-89.
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