Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans

doi:10.1111/ahg.12064

PSYCH OpenIR > 健康与遗传心理学研究室

	Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans
	Levran,Orna 1; Randesi,Matthew 1; Li,Yi 2; Rotrosen,John 3,4; Ott,Jurg 5,6; Adelson,Miriam 1,7; Kreek,MaryJeanne 1
第一作者	Levran, Orna
通讯作者邮箱	levrano@rockefeller.edu
摘要	Stress is a significant risk factor in the development of drug addictions and in addiction relapse susceptibility. This hypothesis-driven study was designed to determine if specific SNPs in genes related to stress response are associated with heroin and/or cocaine addiction in African Americans. The analysis included 27 genes (124 SNPs) and was performed independently for each addiction. The sample consisted of former heroin addicts in methadone maintenance treatment (n = 314), cocaine addicts (n = 281), and controls (n = 208). Fourteen SNPs showed nominally significant association with heroin addiction (p < 0.05), including the African-specific, missense SNP rs5376 (Asn334Ser) in the galanin receptor type 1 gene (GALR1) and the functional FKBP5 intronic SNP rs1360780. Thirteen SNPs showed association with cocaine addiction, including the synonymous SNPs rs237902, in the oxytocin receptor gene (OXTR), and rs5374 in GALR1. No signal remained significant after correction for multiple testing. Four additional SNPs (GALR1 rs2717162, AVP rs2282018, CRHBP rs1875999, and NR3C2 rs1040288) were associated with both addictions and may indicate common liability. The study provides preliminary evidence for novel association of variants in several stress-related genes with heroin and/or cocaine addictions and may enhance the understanding of the interaction between stress and addictions.
关键词	Heroin Addiction Cocaine Addiction African Americans Stress Hpa Axis Galr1 Fkbp5 Nr3c2 Oxtr Avp
学科领域	Genetics & Heredity
	2014-07-01
语种	英语
DOI	10.1111/ahg.12064
发表期刊	ANNALS OF HUMAN GENETICS
ISSN	0003-4800
卷号	78 期号:4 页码:290-298
期刊论文类型	Article
URL	查看原文
收录类别	SCI ; SCI
WOS关键词	SUBSTANCE USE DISORDERS ; HPA AXIS GENES ; CHILDHOOD TRAUMA ; HEROIN-ADDICTION ; PANIC DISORDER ; RECEPTOR GENE ; SUICIDAL-BEHAVIOR ; REWARD PATHWAYS ; CANDIDATE GENES ; FKBP5 GENE
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
WOS记录号	WOS:000337794000005
取样对象	人类
性别	男 ; 女
被试数量	803
测试或任务	genetics of specific drug addictions
因变量指标	association
统计软件	Haploview 4.2, PLINK program
统计方法	Hardy-W einberg equilibrium; Pairwise linkage disequilibrium; logistic regression; Association analysis
引用统计	被引频次：52[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14189
专题	健康与遗传心理学研究室
作者单位	1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA; 2.Shanxi Univ Finance & Econ, Sch Stat, Taiyuan, Shanxi, Peoples R China; 3.VA New York Harbor Healthcare Syst, New York, NY USA; 4.NYU Sch Med, New York, NY USA; 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China; 6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA; 7.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV USA
推荐引用方式 GB/T 7714	Levran,Orna,Randesi,Matthew,Li,Yi,et al. Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans[J]. ANNALS OF HUMAN GENETICS,2014,78(4):290-298.
APA	Levran,Orna.,Randesi,Matthew.,Li,Yi.,Rotrosen,John.,Ott,Jurg.,...&Kreek,MaryJeanne.(2014).Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans.ANNALS OF HUMAN GENETICS,78(4),290-298.
MLA	Levran,Orna,et al."Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans".ANNALS OF HUMAN GENETICS 78.4(2014):290-298.

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