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rSNPBase: a database for curated regulatory SNPs
Guo, Liyuan1; Du, Yang1,2; Chang, Suhua1; Zhang, Kunlin1; Wang, Jing1
2014
Source PublicationNUCLEIC ACIDS RESEARCH
ISSN0305-1048
SubtypeArticle
Volume42Issue:D1Pages:D1033-D1039
AbstractIn recent years, human regulatory SNPs (rSNPs) have been widely studied. Here, we present database rSNPBase, freely available at http://rsnp.psych.ac.cn/, to provide curated rSNPs that analyses the regulatory features of all SNPs in the human genome with reference to experimentally supported regulatory elements. In contrast with previous SNP functional annotation databases, rSNPBase is characterized by several unique features. (i) To improve reliability, all SNPs in rSNPBase are annotated with reference to experimentally supported regulatory elements. (ii) rSNPBase focuses on rSNPs involved in a wide range of regulation types, including proximal and distal transcriptional regulation and post-transcriptional regulation, and identifies their potentially regulated genes. (iii) Linkage disequilibrium (LD) correlations between SNPs were analysed so that the regulatory feature is annotated to SNP-set rather than a single SNP. (iv) rSNPBase provides the spatio-temporal labels and experimental eQTL labels for SNPs. In summary, rSNPBase provides more reliable, comprehensive and user-friendly regulatory annotations on rSNPs and will assist researchers in selecting candidate SNPs for further genetic studies and in exploring causal SNPs for in-depth molecular mechanisms of complex phenotypes.
Indexed BySCI
Language英语
WOS IDWOS:000331139800152
Citation statistics
Cited Times:58[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14192
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guo, Liyuan,Du, Yang,Chang, Suhua,et al. rSNPBase: a database for curated regulatory SNPs[J]. NUCLEIC ACIDS RESEARCH,2014,42(D1):D1033-D1039.
APA Guo, Liyuan,Du, Yang,Chang, Suhua,Zhang, Kunlin,&Wang, Jing.(2014).rSNPBase: a database for curated regulatory SNPs.NUCLEIC ACIDS RESEARCH,42(D1),D1033-D1039.
MLA Guo, Liyuan,et al."rSNPBase: a database for curated regulatory SNPs".NUCLEIC ACIDS RESEARCH 42.D1(2014):D1033-D1039.
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