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rSNPBase: a database for curated regulatory SNPs
Guo, Liyuan1; Du, Yang1,2; Chang, Suhua1; Zhang, Kunlin1; Wang, Jing1
2014
发表期刊NUCLEIC ACIDS RESEARCH
ISSN0305-1048
文章类型Article
卷号42期号:D1页码:D1033-D1039
摘要In recent years, human regulatory SNPs (rSNPs) have been widely studied. Here, we present database rSNPBase, freely available at http://rsnp.psych.ac.cn/, to provide curated rSNPs that analyses the regulatory features of all SNPs in the human genome with reference to experimentally supported regulatory elements. In contrast with previous SNP functional annotation databases, rSNPBase is characterized by several unique features. (i) To improve reliability, all SNPs in rSNPBase are annotated with reference to experimentally supported regulatory elements. (ii) rSNPBase focuses on rSNPs involved in a wide range of regulation types, including proximal and distal transcriptional regulation and post-transcriptional regulation, and identifies their potentially regulated genes. (iii) Linkage disequilibrium (LD) correlations between SNPs were analysed so that the regulatory feature is annotated to SNP-set rather than a single SNP. (iv) rSNPBase provides the spatio-temporal labels and experimental eQTL labels for SNPs. In summary, rSNPBase provides more reliable, comprehensive and user-friendly regulatory annotations on rSNPs and will assist researchers in selecting candidate SNPs for further genetic studies and in exploring causal SNPs for in-depth molecular mechanisms of complex phenotypes.
收录类别SCI
语种英语
WOS记录号WOS:000331139800152
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14192
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Guo, Liyuan,Du, Yang,Chang, Suhua,et al. rSNPBase: a database for curated regulatory SNPs[J]. NUCLEIC ACIDS RESEARCH,2014,42(D1):D1033-D1039.
APA Guo, Liyuan,Du, Yang,Chang, Suhua,Zhang, Kunlin,&Wang, Jing.(2014).rSNPBase: a database for curated regulatory SNPs.NUCLEIC ACIDS RESEARCH,42(D1),D1033-D1039.
MLA Guo, Liyuan,et al."rSNPBase: a database for curated regulatory SNPs".NUCLEIC ACIDS RESEARCH 42.D1(2014):D1033-D1039.
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