Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults

	Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults
	Yu, Jing1,3 ; Su, Tao 2,4; Zhou, Ting1 ; He, Yingge 2; Lu, Jing 2; Li, Juan1 ; He, Rongqiao 2
摘要	Recent studies have shown that the abnormal accumulation of endogenous formaldehyde could be a critical factor in age-related cognitive decline. The aim of this study was to estimate the correlation between uric formaldehyde and general cognitive abilities in a community-based elderly population, and to measure the extent and direction in which the correlation varied with demographic characteristics. Using a double-blind design, formaldehyde in human urine was analyzed by high-performance liquid chromatography (n = 604), and general cognitive abilities were measured using the Montreal Cognitive Assessment (MoCA). Demographic characteristics, in terms of age, gender, residential region, and education were taken into consideration. We found that uric formaldehyde levels were inversely correlated with the MoCA score, and the concentration varied with demographic features: higher odds of a high formaldehyde level occurred among the less educated and those living in old urban or rural areas. In cytological experiments, the level of cellular formaldehyde released into the medium increased as SH-SY5Y and BV2 cells were incubated for three days. Formaldehyde in excess impaired the processes of N2a cells and neurites of primary cultured rat hippocampal cells. However, removal of formaldehyde markedly rescued and regenerated the processes of N2a cells. These results demonstrated a negative correlation between the endogenous formaldehyde and general cognitive abilities. High formaldehyde levels could be a risk factor for cognitive impairment in older adults, and could be developed as a non-invasive marker for detection and monitoring of age-related cognitive impairment.
关键词	uric formaldehyde the Montreal Cognitive Assessment education learning living region
	2014-04-01
语种	英语
发表期刊	NEUROSCIENCE BULLETIN
ISSN	1673-7067
卷号	30 期号:2 页码:172-184
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000334513200002
引用统计	被引频次：44[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14201
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Ctr Ageing Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 3.Southwest Univ, Fac Psychol, Chongqing 400715, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yu, Jing,Su, Tao,Zhou, Ting,et al. Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults[J]. NEUROSCIENCE BULLETIN,2014,30(2):172-184.
APA	Yu, Jing.,Su, Tao.,Zhou, Ting.,He, Yingge.,Lu, Jing.,...&He, Rongqiao.(2014).Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults.NEUROSCIENCE BULLETIN,30(2),172-184.
MLA	Yu, Jing,et al."Uric formaldehyde levels are negatively correlated with cognitive abilities in healthy older adults".NEUROSCIENCE BULLETIN 30.2(2014):172-184.

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