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SELF ADMINISTRATION OF OXYCODONE BY ADOLESCENT AND ADULT MICE AFFECTS STRIATAL NEUROTRANSMITTER RECEPTOR GENE EXPRESSION
Mayer-Blackwell, B.1; Schlussman, S. D.1; Butelman, E. R.1; Ho, A.1; Ott, J.2; Kreek, M. J.1; Zhang, Y.1
2014-01-31
Source PublicationNEUROSCIENCE
ISSN0306-4522
SubtypeArticle
Volume258Issue:0Pages:280-291
AbstractIllicit use of prescription opioid analgesics (e.g., oxycodone) in adolescence is a pressing public health issue. Our goal was to determine whether oxycodone self administration differentially affects striatal neurotransmitter receptor gene expression in the dorsal striatum of adolescent compared to adult C57BL/6J mice. Groups of adolescent mice (4 weeks old, n=12) and of adult mice (11 weeks old, n=11) underwent surgery during which a catheter was implanted into their jugular veins. After recovering from surgery, mice self administered oxycodone (0.25 mg/kg/infusion) 2 h/day for 14 consecutive days or served as yoked saline controls. Mice were sacrificed within 1 h after the last self- administration session and the dorsal striatum was isolated for mRNA analysis. Gene expression was analyzed with real time PCR using a commercially available neurotransmitter receptor PCR array containing 84 genes. We found that adolescent mice self administered less oxycodone than adult mice over the 14 days. Monoamine oxidase A (Maoa) and neuropeptide Y receptor 5 mRNA levels were lower in adolescent mice than in adult mice without oxycodone exposure. Oxycodone self administration increased Maoa mRNA levels compared to controls in both age groups. There was a positive correlation of the amount of oxycodone self administered in the last session or across 14 sessions with Maoa mRNA levels. Gastrinreleasing peptide receptor mRNA showed a significant Drug x Age interaction, with point- wise significance. More genes in the dorsal striatum of adolescents (19) changed in response to oxycodone self administration compared to controls than in adult (4) mice. Overall, this study demonstrates that repeated oxycodone self administration alters neurotransmitter receptors gene expression in the dorsal striatum of adolescent and adult mice. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
Keywordoxycodone adolescent adult self administration neurotransmitter receptor gene expression dorsal striatum
Indexed BySCI
Language英语
WOS IDWOS:000330596900027
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14205
Collection健康与遗传心理学研究室
Affiliation1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Mayer-Blackwell, B.,Schlussman, S. D.,Butelman, E. R.,et al. SELF ADMINISTRATION OF OXYCODONE BY ADOLESCENT AND ADULT MICE AFFECTS STRIATAL NEUROTRANSMITTER RECEPTOR GENE EXPRESSION[J]. NEUROSCIENCE,2014,258(0):280-291.
APA Mayer-Blackwell, B..,Schlussman, S. D..,Butelman, E. R..,Ho, A..,Ott, J..,...&Zhang, Y..(2014).SELF ADMINISTRATION OF OXYCODONE BY ADOLESCENT AND ADULT MICE AFFECTS STRIATAL NEUROTRANSMITTER RECEPTOR GENE EXPRESSION.NEUROSCIENCE,258(0),280-291.
MLA Mayer-Blackwell, B.,et al."SELF ADMINISTRATION OF OXYCODONE BY ADOLESCENT AND ADULT MICE AFFECTS STRIATAL NEUROTRANSMITTER RECEPTOR GENE EXPRESSION".NEUROSCIENCE 258.0(2014):280-291.
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