PSYCH OpenIR  > 健康与遗传心理学研究室
Biological insights from 108 schizophrenia-associated genetic loci
Ripke, Stephan1,2; Neale, Benjamin M.1,2,3,4; Corvin, Aiden5; Walters, James T. R.6; Farh, Kai-How1; Holmans, Peter A.6,7; Lee, Phil1,2,4; Bulik-Sullivan, Brendan1,2; Collier, David A.8,9; Huang, Hailiang1,3; Pers, Tune H.3,10,11,12; Agartz, Ingrid13,14,15; Agerbo, Esben16,17,18; Albus, Margot19; Alexander, Madeline20; Amin, Farooq21,22; Bacanu, Silviu A.23; Begemann, Martin24; Belliveau, Richard A., Jr.2; Bene, Judit25,26; Bergen, Sarah E.2,27; Bevilacqua, Elizabeth2; Bigdeli, Tim B.23; Black, Donald W.28; Bruggeman, Richard29; Buccola, Nancy G.30; Buckner, Randy L.31,32,33; Byerley, William34; Cahn, Wiepke35; Cai, Guiqing36,37; Campion, Dominique38,39; Cantor, Rita M.40; Carr, Vaughan J.41,42; Carrera, Noa6; Catts, Stanley V.41,43; Chambert, Kimberly D.2; Chan, Raymond C. K.44; Chen, Ronald Y. L.45; Chen, Eric Y. H.45,46; Cheng, Wei47; Cheung, Eric F. C.48; Chong, Siow Ann49; Cloninger, C. Robert50; Cohen, David51,52; Cohen, Nadine53; Cormican, Paul5; Craddock, Nick6,7; Crowley, James J.54; Curtis, David55,56; Davidson, Michael57; Davis, Kenneth L.37; Degenhardt, Franziska58,59; Del Favero, Jurgen60; Demontis, Ditte18,61,62; Dikeos, Dimitris63; Dinan, Timothy64; Djurovic, Srdjan15,65; Donohoe, Gary5,66,67; Drapeau, Elodie37; Duan, Jubao68,69; Dudbridge, Frank70; Durmishi, Naser71; Eichhammer, Peter72; Eriksson, Johan73,74,75,76; Escott-Price, Valentina6; Essioux, Laurent77; Fanous, Ayman H.78,79,80,81; Farrell, Martilias S.54; Frank, Josef82; Franke, Lude83; Freedman, Robert84; Freimer, Nelson B.85; Friedl, Marion86; Friedman, Joseph I.37; Fromer, Menachem1,2,4,87; Genovese, Giulio2; Georgieva, Lyudmila6; Giegling, Ina86,88; Giusti-Rodriguez, Paola54; Godard, Stephanie89,90; Goldstein, Jacqueline I.1,3; Golimbet, Vera91; Gopal, Srihari92; Gratten, Jacob93; de Haan, Lieuwe94; Hammer, Christian24; Hamshere, Marian L.6; Hansen, Mark95; Hansen, Thomas18,96; Haroutunian, Vahram37,97,98; Hartmann, Annette M.86; Henskens, Frans A.41,99,100; Herms, Stefan58,59,101; Hirschhorn, Joel N.3,11,12,102; Hoffmann, Per58,59,101; Hofman, Andrea58,59; Hollegaard, Mads V.103; Hougaard, David M.103; Ikeda, Masashi104; Joa, Inge105; Julia, Antonio106; Kahn, Rene S.35; Kalaydjieva, Luba107,108; Karachanak-Yankova, Sena109; Karjalainen, Juha83; Kavanagh, David6; Keller, Matthew C.110; Kennedy, James L.111,112,113; Khrunin, Andrey114; Kim, Yunjung54; Klovins, Janis115; Knowles, James A.116,117; Konte, Bettina86; Kucinskas, Vaidutis118; Kucinskiene, Zita Ausrele118; Kuzelova-Ptackova, Hana119,120; Kahler, Anna K.27; Laurent, Claudine20,121; Keong, Jimmy Lee Chee49,122; Lee, S. Hong93; Legge, Sophie E.6; Lerer, Bernard123; Li, Miaoxin45,46,124; Li, Tao125,126; Liang, Kung-Yee127; Lieberman, Jeffrey128; Limborska, Svetlana114; Loughland, Carmel M.41,129; Lubinski, Jan130; Lonnqvist, Jouko131; Macek, Milan, Jr.119,120; Magnusson, Patrik K. E.27; Maher, Brion S.132; Maier, Wolfgang133; Mallet, Jacques134; Marsal, Sara106; Mattheisen, Manuel18,61,62,135; Mattingsdal, Morten15,136; McCarley, Robert W.137,138; McDonald, Colm139; McIntosh, Andrew M.140,141; Meier, Sandra82; Meijer, Carin J.94; Melegh, Bela25,26; Melle, Ingrid15,142; Mesholam-Gately, Raquelle I.137,143; Metspalu, Andres144; Michie, Patricia T.41,145; Milani, Lili144; Milanova, Vihra146; Mokrab, Younes8; Morris, Derek W.5,66,67; Mors, Ole18,61,147; Murphy, Kieran C.148; Murray, Robin M.149; Myin-Germeys, Inez150; Mueller-Myhsok, Bertram151,152,153; Nelis, Mari144; Nenadic, Igor154; Nertney, Deborah A.155,156; Nestadt, Gerald157; Nicodemus, Kristin K.158; Nikitina-Zake, Liene115; Nisenbaum, Laura159; Nordin, Annelie160; O'Callaghan, Eadbhard161; O'Dushlaine, Colm2; O'Neill, F. Anthony162; Oh, Sang-Yun163; Olincy, Ann84; Olsen, Line18,96; Van Os, Jim150,164; Pantelis, Christos41,165,166; Papadimitriou, George N.63; Papiol, Sergi24; Parkhomenko, Elena37; Pato, Michele T.116,117; Paunio, Tiina167,168; Pejovic-Milovancevic, Milica169; Perkins, Diana O.170; Pietilainen, Olli168,171; Pimm, Jonathan56; Pocklington, Andrew J.6; Powell, John149; Price, Alkes3,172; Pulver, Ann E.157; Purcell, Shaun M.87; Quested, Digby173; Rasmussen, Henrik B.18,96; Reichenberg, Abraham37; Reimers, Mark A.174; Richards, Alexander L.6; Roffman, Joshua L.31,33; Roussos, Panos87,175; Ruderfer, Douglas M.6,87; Salomaa, Veikko76; Sanders, Alan R.68,69; Schall, Ulrich41,129; Schubert, Christian R.176; Schulze, Thomas G.82,177; Schwab, Sibylle G.178; Scolnick, Edward M.2; Scott, Rodney J.41,179,180; Seidman, Larry J.137,143; Shi, Jianxin181; Sigurdsson, Engilbert182; Silagadze, Teimuraz183; Silverman, Jeremy M.37,184; Sim, Kang49; Slominsky, Petr114; Smoller, Jordan W.2,4; So, Hon-Cheong45; Spencer, Chris C. A.185; Stahl, Eli A.3,87; Stefansson, Hreinn186; Steinberg, Stacy186; Stogmann, Elisabeth187; Straub, Richard E.188; Strengman, Eric35,189; Strohmaier, Jana82; Stroup, T. Scott128; Subramaniam, Mythily49; Suvisaari, Jaana131; Svrakic, Dragan M.50; Szatkiewicz, Jin P.54; Soderman, Erik13; Thirumalai, Srinivas190; Toncheva, Draga109; Tosato, Sarah191; Veijola, Juha192,193; Waddington, John194; Walsh, Dermot195; Wang, Dai92; Wang, Qiang125,126; Webb, Bradley T.23; Weiser, Mark57; Wildenauer, Dieter B.196; Williams, Nigel M.6; Williams, Stephanie54; Witt, Stephanie H.82; Wolen, Aaron R.174; Wong, Emily H. M.45; Wormley, Brandon K.23; Xi, Hualin Simon197; Zai, Clement C.111,112; Zheng, Xuebin198; Zimprich, Fritz187; Wray, Naomi R.93; Stefansson, Kari186; Visscher, Peter M.93; Adolfsson, Rolf160; Andreassen, Ole A.15,142; Blackwood, Douglas H. R.141; Bramon, Elvira199; Buxbaum, Joseph D.36,37,97,200; Borglum, Anders D.18,61,62,147; Cichon, Sven58,59,101,201; Darvasi, Ariel202; Domenici, Enrico203; Ehrenreich, Hannelore24; Esko, Tonu3,11,12,102,144; Gejman, Pablo V.68,69; Gill, Michael5; Gurling, Hugh56; Hultman, Christina M.27; Iwata, Nakao104; Jablensky, Assen V.41,108,196,204; Jonsson, Erik G.13,15; Kendler, Kenneth S.205,206; Kirov, George6; Knight, Jo111,112,113; Lencz, Todd207,208,209; Levinson, Douglas F.20; Li, Qingqin S.92; Liu, Jianjun198,210; Malhotra, Anil K.207,208,209; McCarroll, Steven A.2,102; McQuillin, Andrew56; Moran, Jennifer L.2; Mortensen, Preben B.16,17,18; Mowry, Bryan J.93,211; Noethen, Markus M.58,59; Ophoff, Roel A.35,40,85; Owen, Michael J.6,7; Palotie, Aarno2,4,171; Pato, Carlos N.116,117; Petryshen, Tracey L.2,137,212,213; Posthuma, Danielle214,215,216; Rietschel, Marcella82; Riley, Brien P.205,206; Rujescu, Dan86,88; Sham, Pak C.45,46,124; Sklar, Pamela87,97,175; St Clair, David217; Weinberger, Daniel R.188,218,219,220,221; Wendland, Jens R.176; Werge, Thomas18,96,222; Daly, Mark J.1,2,3; Sullivan, Patrick F.27,54,170; O'Donovan, Michael C.6,7; Psychiat Genomics Consortium; Psychosis Endophenotypes Int Conso; Wellcome Trust Case-Control Consor
2014-07-24
发表期刊NATURE
ISSN0028-0836
文章类型Article
卷号511期号:7510页码:421-+
摘要Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
收录类别SCI
语种英语
WOS记录号WOS:000339335700037
引用统计
被引频次:2263[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14207
专题健康与遗传心理学研究室
作者单位1.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
2.Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA
3.Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA 02142 USA
4.Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
5.Univ Ireland Trinity Coll, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland
6.Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales
7.Cardiff Univ, Natl Ctr Mental Hlth, Cardiff CF24 4HQ, S Glam, Wales
8.Eli Lilly & Co Ltd, Erl Wood Manor, Windlesham GU20 6PH, Surrey, England
9.Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
10.Tech Univ Denmark, Dept Syst Biol, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark
11.Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
12.Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA
13.Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, SE-17176 Stockholm, Sweden
14.Diakonhjemmet Hosp, Dept Psychiat, N-0319 Oslo, Norway
15.Univ Oslo, Inst Clin Med, KG Jebsen Ctr Psychosis Res, NORMENT, N-0424 Oslo, Norway
16.Aarhus Univ, CIRRAU, Ctr Integrat Register Based Res, DK-8210 Aarhus, Denmark
17.Aarhus Univ, Natl Ctr Register Based Res, DK-8210 Aarhus, Denmark
18.Lundbeck Fdn Initiat Integrat Psychiat Res, iPSYCH, Aarhus, Denmark
19.State Mental Hosp, D-85540 Haar, Germany
20.Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
21.Atlanta Vet Affairs Med Ctr, Dept Psychiat & Behav Sci, Atlanta, GA 30033 USA
22.Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
23.Virginia Commonwealth Univ, Dept Psychiat, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA
24.Max Planck Inst Expt Med, D-37075 Gottingen, Germany
25.Univ Pecs, Dept Med Genet, H-7624 Pecs, Hungary
26.Univ Pecs, Szentagothai Res Ctr, H-7624 Pecs, Hungary
27.Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden
28.Univ Iowa, Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA
29.Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9700 RB Groningen, Netherlands
30.Louisiana State Univ, Hlth Sci Ctr, Sch Nursing, New Orleans, LA 70112 USA
31.Massachusetts Gen Hosp, Athinoula A Martinos Ctr, Boston, MA 02129 USA
32.Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA
33.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
34.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA
35.Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, NL-3584 Utrecht, Netherlands
36.Icahn Sch Med Mt Sinai, Dept Human Genet, New York, NY 10029 USA
37.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
38.Ctr Hosp Rouvray, F-76301 Rouen, France
39.INSERM, U1079, Fac Med, F-76301 Rouen, France
40.Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA
41.Schizophrenia Res Inst, Sydney, NSW 2010, Australia
42.Univ New S Wales, Sch Psychiat, Sydney, NSW 2031, Australia
43.Univ Queensland, Royal Brisbane & Womens Hosp, St Lucia, Qld 4072, Australia
44.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
45.Univ Hong Kong, Li Ka Shing Fac Med, Dept Psychiat, Hong Kong, Hong Kong, Peoples R China
46.Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci, Hong Kong, Hong Kong, Peoples R China
47.Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27514 USA
48.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
49.Inst Mental Hlth, Singapore 539747, Singapore
50.Washington Univ, Dept Psychiat, St Louis, MO 63110 USA
51.Assistance Publ Hop Paris, Dept Child & Adolescent Psychiat, Pierre & Marie Curie Fac Med, F-75013 Paris, France
52.Inst Intelligent Syst & Robot, F-75013 Paris, France
53.Blue Note Biosci, Princeton, NJ 08540 USA
54.Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
55.Queen Mary Univ London, Dept Psychol Med, London E1 1BB, England
56.UCL, Mol Psychiat Lab, Div Psychiat, London WC1E 6JJ, England
57.Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel
58.Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany
59.Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany
60.Univ Antwerp VIB, Dept Mol Genet, Appl Mol Genom Unit, B-2610 Antwerp, Belgium
61.Aarhus Univ, iSEQ, Ctr Integrat Sequencing, DK-8000 Aarhus C, Denmark
62.Aarhus Univ, Dept Biomed, DK-8000 Aarhus C, Denmark
63.Univ Athens, Sch Med, Dept Psychiat 1, Athens 11528, Greece
64.Univ Coll Cork, Dept Psychiat, Cork, Ireland
65.Oslo Univ Hosp, Dept Med Genet, N-0424 Oslo, Norway
66.Natl Univ Ireland Galway, Cognit Genet & Therapy Grp, Sch Psychol, Galway, Ireland
67.Natl Univ Ireland Galway, Discipline Biochem, Galway, Ireland
68.Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA
69.NorthShore Univ HealthSyst, Dept Psychiat & Biobehav Sci, Evanston, IL 60201 USA
70.Univ London London Sch Hyg & Trop Med, Dept Noncommunicable Dis Epidemiol, London WC1E 7HT, England
71.Univ Clin Psychiat, Dept Child & Adolescent Psychiat, Skopje 1000, Macedonia
72.Univ Regensburg, Dept Psychiat, D-93053 Regensburg, Germany
73.Univ Helsinki, Cent Hosp, Dept Gen Practice, FI-00014 Helsinki, Finland
74.Folkhalsan Res Ctr, Helsinki, Finland
75.Biomedicum Helsinki 1, FI-00290 Helsinki, Finland
76.Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
77.F Hoffmann La Roche & Co Ltd, Pharma Res & Early Dev, Translat Technol & Bioinformat, CH-4070 Basel, Switzerland
78.Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC 20057 USA
79.Univ So Calif, Keck Sch Med, Dept Psychiat, Los Angeles, CA 90033 USA
80.Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA 23298 USA
81.Washington VA Med Ctr, Washington, DC 20422 USA
82.Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany
83.Univ Groningen, Univ Med Ctr Groningen, Dept Genet, NL-9700 RB Groningen, Netherlands
84.Univ Colorado Denver, Dept Psychiat, Aurora, CO 80045 USA
85.Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA 90095 USA
86.Univ Halle Wittenberg, Dept Psychiat, D-06112 Halle, Germany
87.Icahn Sch Med Mt Sinai, Dept Psychiat, Div Psychiat Genom, New York, NY USA
88.Univ Munich, Dept Psychiat, D-80336 Munich, Germany
89.Hop La Pitie Salpetriere, Dept Psychiat, INSERM, Inst Myol, F-75013 Paris, France
90.Hop La Pitie Salpetriere, Dept Human & Mol Genet, INSERM, Inst Myol, F-75013 Paris, France
91.Russian Acad Med Sci, Mental Hlth Res Ctr, Moscow 115522, Russia
92.Janssen Res & Dev, Neurosci Therapeut Area, Raritan, NJ 08869 USA
93.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
94.Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 AZ Amsterdam, Netherlands
95.Illumina, La Jolla, CA 92122 USA
96.Mental Hlth Serv Copenhagen, Mental Hlth Ctr Sct Hans, Inst Biol Psychiat, DK-4000 Roskilde, Denmark
97.Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
98.JJ Peters VA Med Ctr, Bronx, NY 10468 USA
99.Univ Newcastle, Prior Res Ctr Hlth Behav, Newcastle, NSW 2308, Australia
100.Univ Newcastle, Sch Elect Engn & Comp Sci, Newcastle, NSW 2308, Australia
101.Univ Basel, Dept Biomed, Div Med Genet, CH-4058 Basel, Switzerland
102.Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
103.Statens Serum Inst, Dept Clin Biochem Immunol & Genet, Sect Neonatal Screening & Hormones, DK-2300 Copenhagen, Denmark
104.Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan
105.Stavanger Univ Hosp, Dept Psychiat, Reg Ctr Clin Res Psychosis, N-4011 Stavanger, Norway
106.Vall dHebron Res Inst, Rheumatol Res Grp, Barcelona 08035, Spain
107.Univ Western Australia, Ctr Med Res, Perth, WA 6009, Australia
108.Univ Western Australia, Perkins Inst Med Res, Perth, WA 6009, Australia
109.Med Univ, Dept Med Genet, Sofia 1431, Bulgaria
110.Univ Colorado, Dept Psychol, Boulder, CO 80309 USA
111.Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON M5T 1R8, Canada
112.Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada
113.Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
114.Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
115.Latvian Biomed Res & Study Ctr, LV-1067 Riga, Latvia
116.Univ So Calif, Dept Psychiat, Los Angeles, CA 90089 USA
117.Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90089 USA
118.Vilnius State Univ, Fac Med, LT-01513 Vilnius, Lithuania
119.2nd Fac Med, Dept Biol & Med Genet, Prague 15006, Czech Republic
120.Univ Hosp Motol, Prague 15006, Czech Republic
121.Pierre & Marie Curie Fac Med, Dept Child & Adolescent Psychiat, F-75013 Paris, France
122.Duke NUS Grad Med Sch, Singapore 169857, Singapore
123.Hadassah Hebrew Univ, Med Ctr, Dept Psychiat, IL-91120 Jerusalem, Israel
124.Univ Hong Kong, Ctr Genom Sci, Hong Kong, Hong Kong, Peoples R China
125.Sichuan Univ, Mental Hlth Ctr, Chengdu 610041, Sichuan, Peoples R China
126.Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu 610041, Sichuan, Peoples R China
127.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD 21205 USA
128.Columbia Univ, Dept Psychiat, New York, NY 10032 USA
129.Univ Newcastle, Prior Ctr Translat Neurosci & Mental Hlth, Newcastle, NSW 2300, Australia
130.Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70453 Szczecin, Poland
131.Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, FI-00271 Helsinki, Finland
132.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA
133.Univ Bonn, Dept Psychiat, D-53127 Bonn, Germany
134.Hop La Pitie Salpetriere, CNRS, Lab Genet Mol Neurotransmiss & Proc Neurodegenera, F-75013 Paris, France
135.Univ Bonn, Dept Genom Math, D-53127 Bonn, Germany
136.Sorlandet Hosp, Res Unit, N-4604 Kristiansand, Norway
137.Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
138.VA Boston Hlth Care Syst, Brockton, MA 02301 USA
139.Natl Univ Ireland Galway, Dept Psychiat, Galway, Ireland
140.Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH16 4SB, Midlothian, Scotland
141.Univ Edinburgh, Div Psychiat, Edinburgh EH16 4SB, Midlothian, Scotland
142.Oslo Univ Hosp, Div Mental Hlth & Addict, N-0424 Oslo, Norway
143.Beth Israel Deaconess Med Ctr, Publ Psychiat Div, Massachusetts Mental Hlth Ctr, Boston, MA 02114 USA
144.Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia
145.Univ Newcastle, Sch Psychol, Callaghan, NSW 2308, Australia
146.Med Univ, Psychiat Clin 1, Sofia 1431, Bulgaria
147.Aarhus Univ Hosp, Dept P, DK-8240 Risskov, Denmark
148.Royal Coll Surgeons Ireland, Dept Psychiat, Dublin 2, Ireland
149.Kings Coll London, London SE5 8AF, England
150.Maastricht Univ, Med Ctr, South Limburg Mental Hlth Res & Teaching Network, EURON, NL-6229 HX Maastricht, Netherlands
151.Univ Liverpool, Inst Translat Med, Liverpool L69 3BX, Merseyside, England
152.Max Planck Inst Psychiat, D-80336 Munich, Germany
153.Munich Cluster Syst Neurol SyNergy, D-80336 Munich, Germany
154.Jena Univ Hosp, Dept Psychiat & Psychotherapy, D-07743 Jena, Germany
155.Univ Queensland, Queensland Brain Inst, Dept Psychiat, St Lucia, Qld 4072, Australia
156.Univ Queensland, Queensland Ctr Mental Hlth Res, St Lucia, Qld 4072, Australia
157.Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA
158.Univ Dublin Trinity Coll, Dept Psychiat, Dublin 2, Ireland
159.Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
160.Umea Univ, Dept Clin Sci, SE-90187 Umea, Sweden
161.DETECT Early Intervent Serv Psychosis, Blackrock, Dublin, Ireland
162.Queens Univ Belfast, Inst Clin Sci, Ctr Publ Hlth, Belfast BT12 6AB, Antrim, North Ireland
163.Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA
164.Kings Coll London, Inst Psychiat, London SE5 8AF, England
165.Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic 3053, Australia
166.Melbourne Hlth, Melbourne, Vic 3053, Australia
167.Univ Helsinki, Dept Psychiat, FI-00029 Helsinki, Finland
168.Natl Inst Hlth & Welf, Publ Hlth Genom Unit, FI-00271 Helsinki, Finland
169.Univ Belgrade, Fac Med, Belgrade 11000, Serbia
170.Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
171.Univ Helsinki, FIMM, FI-00014 Helsinki, Finland
172.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
173.Univ Oxford, Dept Psychiat, Oxford OX3 7JX, England
174.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Richmond, VA 23298 USA
175.Icahn Sch Med Mt Sinai, Inst Multiscale Biol, New York, NY 10029 USA
176.Pfizer Worldwide Res & Dev, Pharma Therapeut Clin Res, Cambridge, MA 02139 USA
177.Univ Gottingen, Dept Psychiat & Psychotherapy, D-37073 Gottingen, Germany
178.Univ Erlangen Nurnberg, Psychiat & Psychotherapy Clin, D-91054 Erlangen, Germany
179.Hunter New England Hlth Serv, Newcastle, NSW 2308, Australia
180.Univ Newcastle, Sch Biomed Sci, Newcastle, NSW 2308, Australia
181.NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
182.Univ Iceland, Natl Univ Hosp, Landspitali, IS-101 Reykjavik, Iceland
183.Tbilisi State Med Univ TSMU, Dept Psychiat & Drug Addict, GE-0177 Tbilisi, Rep of Georgia
184.Bronx Vet Affairs Med Ctr, New York, NY 10468 USA
185.Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
186.deCODE Genet, IS-101 Reykjavik, Iceland
187.Med Univ Vienna, Dept Clin Neurol, A-1090 Vienna, Austria
188.Lieber Inst Brain Dev, Baltimore, MD 21205 USA
189.Univ Med Ctr Utrecht, Dept Med Genet, NL-3584 CG Utrecht, Netherlands
190.Berkshire Healthcare NHS Fdn Trust, Bracknell RG12 1BQ, Berks, England
191.Univ Verona, Sect Psychiat, I-37134 Verona, Italy
192.Univ Oulu, Dept Psychiat, Oulu 90014, Finland
193.Univ Hosp Oulu, Oys 90029, Finland
194.Royal Coll Surgeons Ireland, Dublin 2, Ireland
195.Hlth Res Board, Dublin 2, Ireland
196.Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia
197.Pfizer Worldwide Res & Dev, Computat Sci CoE, Cambridge, MA 02139 USA
198.ASTAR, Genome Inst Singapore, Singapore 138672, Singapore
199.UCL, London WC1E 6BT, England
200.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA
201.Res Ctr Juelich, Inst Neurosci & Med INM 1, D-52428 Julich, Germany
202.Hebrew Univ Jerusalem, Dept Genet, IL-91905 Jerusalem, Israel
203.F Hoffmann La Roche & Co Ltd, Pharma Res & Early Dev, Neurosci Discovery & Translat Area, CH-4070 Basel, Switzerland
204.Univ Western Australia, Sch Psychiat & Clin Neurosci, Ctr Clin Res Neuropsychiat, Perth, WA 6000, Australia
205.Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA 23298 USA
206.Virginia Commonwealth Univ, Dept Human & Mol Genet, Richmond, VA 23298 USA
207.Feinstein Inst Med Res, Manhasset, NY 11030 USA
208.Hofstra NS LIJ Sch Med, Hempstead, NY 11549 USA
209.Zucker Hillside Hosp, Glen Oaks, NY 11004 USA
210.Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117597, Singapore
211.Univ Queensland, Queensland Ctr Mental Hlth Res, Brisbane, Qld 4076, Australia
212.Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
213.Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
214.Erasmus Univ, Med Ctr, Dept Child & Adolescent Psychiat, NL-3000 Rotterdam, Netherlands
215.Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Complex Trait Genet, NL-1081 Amsterdam, Netherlands
216.Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Funct Genom, NL-1081 Amsterdam, Netherlands
217.Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland
218.Johns Hopkins Sch Med, Dept Psychiat, Baltimore, MD 21205 USA
219.Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD 21205 USA
220.Johns Hopkins Sch Med, Dept Neurosci, Baltimore, MD 21205 USA
221.Johns Hopkins Sch Med, Inst Med Genet, Baltimore, MD 21205 USA
222.Univ Copenhagen, Dept Clin Med, DK-2200 Copenhagen, Denmark
推荐引用方式
GB/T 7714
Ripke, Stephan,Neale, Benjamin M.,Corvin, Aiden,et al. Biological insights from 108 schizophrenia-associated genetic loci[J]. NATURE,2014,511(7510):421-+.
APA Ripke, Stephan.,Neale, Benjamin M..,Corvin, Aiden.,Walters, James T. R..,Farh, Kai-How.,...&Wellcome Trust Case-Control Consor.(2014).Biological insights from 108 schizophrenia-associated genetic loci.NATURE,511(7510),421-+.
MLA Ripke, Stephan,et al."Biological insights from 108 schizophrenia-associated genetic loci".NATURE 511.7510(2014):421-+.
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