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Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine
Guan, Xi-ting1,2; Shao, Feng3; Xie, Xi1,2; Chen, Lin4; Wang, Weiwen2
2014-09-01
Source PublicationPHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
SubtypeArticle
Volume124Issue:0Pages:361-366
AbstractAspirin (ASP) is the most commonly used non-steroidal anti-inflammatory drug in the world. Recent clinical and preclinical evidence suggests that ASP may also exert psychoactive effects. It remains unclear whether ASP has antidepressant-like activity, and any molecular mechanisms underlying such activity have yet to be elucidated. Using the forced swimming test (FST), a well-established animal model of depression widely used to screen potential antidepressants in rodents, we investigated the effects of subacute treatment with ASP (0, 6, 12, 25, and 50 mg/kg, i.p.) on immobility in the FST, and on FST-induced changes in endocrine and immune parameters in rats, in comparison to the clinical antidepressants imipramine (IMI) and fluoxetine (FLU). Serum levels of corticosterone, pro-inflammatory cytokine interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were determined by enzyme-linked immunosorbent assay. ASP dose-dependently decreased immobility in the FST, without altering the locomotor activity in the open-field test. The inhibitory effects of higher doses (25 and 50 mg/kg) of ASP on immobility were similar to that of FLU and IMI at a dose of 10 mg/kg. In addition, the levels of corticosterone, IL-6, and TNF-alpha in peripheral blood were significantly increased after the FST exposure. IMI, but not FLU and ASP at any dose tested, significantly attenuated corticosterone responses in the FST. Both FLU and IMI treatment reduced the increase of IL-6 and TNF-a levels following the FST exposure. ASP dose-dependently decreased FST-induced increase of cytokine levels, as manifested by significantly stronger effects on IL-6 and TNF-alpha levels at higher doses (25 and 50 mg/kg) than the lowest dose of ASP (6 mg/kg). In all, these results indicate that ASP treatment dose-dependently decreased the immobility time and the release of pro-inflammatory cytokines in the FST suggesting that the anti-inflammatory effects of ASP might be involved in the antidepressant-like effect. (C) 2014 Elsevier Inc. All rights reserved.
KeywordAspirin Antidepressant Forced Swimming Test Corticosterone Il-6 Tnf-alpha
Indexed BySCI
Language英语
WOS IDWOS:000343621900051
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Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14213
Collection中国科学院心理健康重点实验室
Affiliation1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China
4.Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Guan, Xi-ting,Shao, Feng,Xie, Xi,et al. Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,124(0):361-366.
APA Guan, Xi-ting,Shao, Feng,Xie, Xi,Chen, Lin,&Wang, Weiwen.(2014).Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,124(0),361-366.
MLA Guan, Xi-ting,et al."Effects of aspirin on immobile behavior and endocrine and immune changes in the forced swimming test: Comparison to fluoxetine and imipramine".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 124.0(2014):361-366.
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