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Anti-inflammatory Cytokines and Depression
Xu Yue1,2; Lin Wen-Juan1
AbstractIn recent years, the cytokine hypothesis of depression has received considerable research attention, providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10, interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-beta, and adiponectin, show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall, accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression.
KeywordDepression Cytokines Anti-inflammatory Cytokines Anti-inflammation Antidepressant
Indexed BySCI
WOS IDWOS:000345267500002
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Xu Yue,Lin Wen-Juan. Anti-inflammatory Cytokines and Depression[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(11):1099-1108.
APA Xu Yue,&Lin Wen-Juan.(2014).Anti-inflammatory Cytokines and Depression.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,41(11),1099-1108.
MLA Xu Yue,et al."Anti-inflammatory Cytokines and Depression".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41.11(2014):1099-1108.
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