Anti-inflammatory Cytokines and Depression

	Anti-inflammatory Cytokines and Depression
	Xu Yue 1,2; Lin Wen-Juan1
摘要	In recent years, the cytokine hypothesis of depression has received considerable research attention, providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10, interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-beta, and adiponectin, show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall, accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression.
关键词	Depression Cytokines Anti-inflammatory Cytokines Anti-inflammation Antidepressant
	2014-11-01
语种	英语
发表期刊	PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN	1000-3282
卷号	41 期号:11 页码:1099-1108
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000345267500002
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14222
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Xu Yue,Lin Wen-Juan. Anti-inflammatory Cytokines and Depression[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(11):1099-1108.
APA	Xu Yue,&Lin Wen-Juan.(2014).Anti-inflammatory Cytokines and Depression.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,41(11),1099-1108.
MLA	Xu Yue,et al."Anti-inflammatory Cytokines and Depression".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41.11(2014):1099-1108.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Anti-inflammatory Cy（390KB）	期刊论文	作者接受稿	暂不开放	CC BY-NC-SA	请求全文