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题名:
Anti-inflammatory Cytokines and Depression
作者: Xu Yue1,2; Lin Wen-Juan1
文章类型: Article
关键词: depression ; cytokines ; anti-inflammatory cytokines ; anti-inflammation ; antidepressant
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN号: 1000-3282
出版日期: 2014-11-01
卷号: 41, 期号:11, 页码:1099-1108
收录类别: SCI
英文摘要: In recent years, the cytokine hypothesis of depression has received considerable research attention, providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10, interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-beta, and adiponectin, show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall, accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression.
语种: 英语
WOS记录号: WOS:000345267500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/14222
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China

Recommended Citation:
Xu Yue,Lin Wen-Juan. Anti-inflammatory Cytokines and Depression[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(11):1099-1108.
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