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Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance
Ivanov, Iliyan1; Liu, Xun1,3; Clerkin, Suzanne1; Schulz, Kurt1; Fan, Jin1,2,4; Friston, Karl5; London, Edythe D.6,7,8; Schwartz, Jeffrey6; Newcorn, Jeffrey H.1
2014-06-01
Source PublicationEUROPEAN NEUROPSYCHOPHARMACOLOGY
ISSN0924-977X
SubtypeArticle
Volume24Issue:6Pages:897-906
AbstractPsychostimulants, such as methylphenidate, are thought to improve information processing in motivation-reward and attention-activation networks by enhancing the effects of more relevant signals and suppressing those of less relevant ones; however the nature of such reciprocal influences remains poorly understood. To explore this question, we tested the effect of methylphenidate on performance and associated brain activity in the Anticipation, Conflict, Reward (ACR) task. Sixteen healthy adult volunteers, ages 21-45, were scanned twice using functional magnetic resonance imaging (fMRI) as they performed the ACR task under placebo and methylphenidate conditions. A three-way repeated measures analysis of variance, with cue (reward vs. non-reward), target (congruent vs. incongruent) and medication condition (methylphenidate vs. placebo) as the factors, was used to analyze behaviors on the task. Blood oxygen level dependent (BOLD) signals, reflecting task-related neural activity, were evaluated using linear contrasts. Participants exhibited significantly greater accuracy in the methylphenidate condition than the placebo condition. Compared with placebo, the methylphenidate condition also was associated with lesser task-related activity in components of attention-activation systems irrespective of the reward cue, and less task-related activity in components of the reward-motivation system, particularly the insula, during reward trials irrespective of target difficulty. These results suggest that methylphenidate enhances task performance by improving efficiency of information processing in both reward-motivation and in attention-activation systems. Published by Elsevier B.V.
KeywordfMRI Stimulants Insula Reward Attention
Indexed BySCI
Language英语
WOS IDWOS:000336871900008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14226
Collection中国科学院行为科学重点实验室
Affiliation1.Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
2.Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
4.CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
5.UCL, Wellcome Trust Ctr Neuroimaging, London, England
6.Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
7.Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA USA
8.Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA
Recommended Citation
GB/T 7714
Ivanov, Iliyan,Liu, Xun,Clerkin, Suzanne,et al. Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2014,24(6):897-906.
APA Ivanov, Iliyan.,Liu, Xun.,Clerkin, Suzanne.,Schulz, Kurt.,Fan, Jin.,...&Newcorn, Jeffrey H..(2014).Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance.EUROPEAN NEUROPSYCHOPHARMACOLOGY,24(6),897-906.
MLA Ivanov, Iliyan,et al."Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance".EUROPEAN NEUROPSYCHOPHARMACOLOGY 24.6(2014):897-906.
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