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Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance
Ivanov, Iliyan1; Liu, Xun1,3; Clerkin, Suzanne1; Schulz, Kurt1; Fan, Jin1,2,4; Friston, Karl5; London, Edythe D.6,7,8; Schwartz, Jeffrey6; Newcorn, Jeffrey H.1
2014-06-01
发表期刊EUROPEAN NEUROPSYCHOPHARMACOLOGY
ISSN0924-977X
文章类型Article
卷号24期号:6页码:897-906
摘要Psychostimulants, such as methylphenidate, are thought to improve information processing in motivation-reward and attention-activation networks by enhancing the effects of more relevant signals and suppressing those of less relevant ones; however the nature of such reciprocal influences remains poorly understood. To explore this question, we tested the effect of methylphenidate on performance and associated brain activity in the Anticipation, Conflict, Reward (ACR) task. Sixteen healthy adult volunteers, ages 21-45, were scanned twice using functional magnetic resonance imaging (fMRI) as they performed the ACR task under placebo and methylphenidate conditions. A three-way repeated measures analysis of variance, with cue (reward vs. non-reward), target (congruent vs. incongruent) and medication condition (methylphenidate vs. placebo) as the factors, was used to analyze behaviors on the task. Blood oxygen level dependent (BOLD) signals, reflecting task-related neural activity, were evaluated using linear contrasts. Participants exhibited significantly greater accuracy in the methylphenidate condition than the placebo condition. Compared with placebo, the methylphenidate condition also was associated with lesser task-related activity in components of attention-activation systems irrespective of the reward cue, and less task-related activity in components of the reward-motivation system, particularly the insula, during reward trials irrespective of target difficulty. These results suggest that methylphenidate enhances task performance by improving efficiency of information processing in both reward-motivation and in attention-activation systems. Published by Elsevier B.V.
关键词fMRI Stimulants Insula Reward Attention
收录类别SCI
语种英语
WOS记录号WOS:000336871900008
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14226
专题中国科学院行为科学重点实验室
作者单位1.Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
2.Mt Sinai Sch Med, Dept Neurosci, New York, NY 10029 USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
4.CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
5.UCL, Wellcome Trust Ctr Neuroimaging, London, England
6.Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
7.Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA USA
8.Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90024 USA
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Ivanov, Iliyan,Liu, Xun,Clerkin, Suzanne,et al. Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2014,24(6):897-906.
APA Ivanov, Iliyan.,Liu, Xun.,Clerkin, Suzanne.,Schulz, Kurt.,Fan, Jin.,...&Newcorn, Jeffrey H..(2014).Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance.EUROPEAN NEUROPSYCHOPHARMACOLOGY,24(6),897-906.
MLA Ivanov, Iliyan,et al."Methylphenidate and brain activity in a reward/conflict paradigm: Role of the insula in task performance".EUROPEAN NEUROPSYCHOPHARMACOLOGY 24.6(2014):897-906.
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