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Integration of animal behaviors under stresses with different time courses
Zheng, Lun1; Zheng, Xigeng2
AbstractWe used animal models of "forced swim stress" and "chronic unpredictable stress", and tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates floating and anhedonia behaviors. Our results confirmed that depression-prone rats use "floating behavior" as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress; that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia.
KeywordNerve Regeneration Brain Injury Depression Stress Resistance Susceptible To Depression Chronic Unpredictable Stress Forced Swim Dopamine Nucleus Accumbens Nsfc Grant Neural Regeneration
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Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
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GB/T 7714
Zheng, Lun,Zheng, Xigeng. Integration of animal behaviors under stresses with different time courses[J]. NEURAL REGENERATION RESEARCH,2014,9(15):1464-1473.
APA Zheng, Lun,&Zheng, Xigeng.(2014).Integration of animal behaviors under stresses with different time courses.NEURAL REGENERATION RESEARCH,9(15),1464-1473.
MLA Zheng, Lun,et al."Integration of animal behaviors under stresses with different time courses".NEURAL REGENERATION RESEARCH 9.15(2014):1464-1473.
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