Integration of animal behaviors under stresses with different time courses

	Integration of animal behaviors under stresses with different time courses
	Zheng, Lun1 ; Zheng, Xigeng2
摘要	We used animal models of "forced swim stress" and "chronic unpredictable stress", and tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates floating and anhedonia behaviors. Our results confirmed that depression-prone rats use "floating behavior" as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress; that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia.
关键词	Nerve Regeneration Brain Injury Depression Stress Resistance Susceptible To Depression Chronic Unpredictable Stress Forced Swim Dopamine Nucleus Accumbens Nsfc Grant Neural Regeneration
	2014-08-01
语种	英语
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	9 期号:15 页码:1464-1473
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000342650400011
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14228
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Zheng, Lun,Zheng, Xigeng. Integration of animal behaviors under stresses with different time courses[J]. NEURAL REGENERATION RESEARCH,2014,9(15):1464-1473.
APA	Zheng, Lun,&Zheng, Xigeng.(2014).Integration of animal behaviors under stresses with different time courses.NEURAL REGENERATION RESEARCH,9(15),1464-1473.
MLA	Zheng, Lun,et al."Integration of animal behaviors under stresses with different time courses".NEURAL REGENERATION RESEARCH 9.15(2014):1464-1473.

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