TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors

	TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
	Cao, Chengqi 1,2; Wang, Li1 ; Wang, Richu1,2 ; Qing, Yulan 1,2; Zhang, Jianxin1
摘要	Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.
关键词	Association Study Females Post-traumatic Stress Disorder Single-nucleotide Polymorphism Tryptophan Hydroxylase 2
	2014-12-01
语种	英语
发表期刊	PSYCHIATRIC GENETICS
ISSN	0955-8829
卷号	24 期号:6 页码:257-261
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000344918900004
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://ir.psych.ac.cn/handle/311026/14230
专题	中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China
第一作者单位	中国科学院心理健康重点实验室
推荐引用方式 GB/T 7714	Cao, Chengqi,Wang, Li,Wang, Richu,et al. TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors[J]. PSYCHIATRIC GENETICS,2014,24(6):257-261.
APA	Cao, Chengqi,Wang, Li,Wang, Richu,Qing, Yulan,&Zhang, Jianxin.(2014).TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors.PSYCHIATRIC GENETICS,24(6),257-261.
MLA	Cao, Chengqi,et al."TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors".PSYCHIATRIC GENETICS 24.6(2014):257-261.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
WOS_000344918900004.（358KB）	期刊论文	出版稿	暂不开放	CC BY-NC-SA	请求全文