PSYCH OpenIR  > 中国科学院心理健康重点实验室
TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
Cao, Chengqi1,2; Wang, Li1; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1
2014-12-01
Source PublicationPSYCHIATRIC GENETICS
ISSN0955-8829
SubtypeArticle
Volume24Issue:6Pages:257-261
AbstractGenetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.
KeywordAssociation Study Females Post-traumatic Stress Disorder Single-nucleotide Polymorphism Tryptophan Hydroxylase 2
Indexed BySCI
Language英语
WOS IDWOS:000344918900004
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14230
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Cao, Chengqi,Wang, Li,Wang, Richu,et al. TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors[J]. PSYCHIATRIC GENETICS,2014,24(6):257-261.
APA Cao, Chengqi,Wang, Li,Wang, Richu,Qing, Yulan,&Zhang, Jianxin.(2014).TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors.PSYCHIATRIC GENETICS,24(6),257-261.
MLA Cao, Chengqi,et al."TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors".PSYCHIATRIC GENETICS 24.6(2014):257-261.
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