PSYCH OpenIR  > 中国科学院心理健康重点实验室
TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
Cao, Chengqi1,2; Wang, Li1; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1
2014-12-01
发表期刊PSYCHIATRIC GENETICS
ISSN0955-8829
文章类型Article
卷号24期号:6页码:257-261
摘要Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.
关键词Association Study Females Post-traumatic Stress Disorder Single-nucleotide Polymorphism Tryptophan Hydroxylase 2
收录类别SCI
语种英语
WOS记录号WOS:000344918900004
引用统计
被引频次[WOS]:3
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14230
专题中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Cao, Chengqi,Wang, Li,Wang, Richu,et al. TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors[J]. PSYCHIATRIC GENETICS,2014,24(6):257-261.
APA Cao, Chengqi,Wang, Li,Wang, Richu,Qing, Yulan,&Zhang, Jianxin.(2014).TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors.PSYCHIATRIC GENETICS,24(6),257-261.
MLA Cao, Chengqi,et al."TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors".PSYCHIATRIC GENETICS 24.6(2014):257-261.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS_000344918900004.(358KB)期刊论文出版稿暂不开放CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cao, Chengqi]的文章
[Wang, Li]的文章
[Wang, Richu]的文章
百度学术
百度学术中相似的文章
[Cao, Chengqi]的文章
[Wang, Li]的文章
[Wang, Richu]的文章
必应学术
必应学术中相似的文章
[Cao, Chengqi]的文章
[Wang, Li]的文章
[Wang, Richu]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。