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题名:
TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
作者: Cao, Chengqi1,2; Wang, Li(王力)1; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1
文章类型: Article
关键词: association study ; females ; post-traumatic stress disorder ; single-nucleotide polymorphism ; tryptophan hydroxylase 2
刊名: PSYCHIATRIC GENETICS
ISSN号: 0955-8829
出版日期: 2014-12-01
卷号: 24, 期号:6, 页码:257-261
收录类别: SCI
英文摘要: Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms.
语种: 英语
WOS记录号: WOS:000344918900004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/14230
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China

Recommended Citation:
Cao, Chengqi,Wang, Li,Wang, Richu,et al. TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors[J]. PSYCHIATRIC GENETICS,2014,24(6):257-261.
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