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Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats
Chen, Weihai1,2; Zhang, Qi1,2; Su, Wenxin1,2; Zhang, Haorong1,2; Yang, Yu1,2; Qiao, Jing1,2; Sui, Nan3; Li, Ming4
2014-02-01
发表期刊PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN0091-3057
文章类型Article
卷号117期号:0页码:25-33
摘要Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression - and its known interaction with dopamine - it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study, we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats. We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT2A receptors would produce a functionally equivalent disruption of maternal behavior because these two receptor subtypes often exert opposite effects on various brain functions and psychological processes relevant to rat maternal behavior. On postpartum Days 5, 7, and 9, Sprague-Dawley mother rats were given a single injection of 0.9% NaCl solution, the 5-HT2C agonist MK212 (0.5, 1.0 or 2.0 mg/kg, ip), or the 5-HT2A antagonist MDL100907 (0.05, 0.5 or 2.0 mg/kg, ip). Maternal behavior was tested 30 min before and 30 min, 120 min, 240 min after injection. Acute injection of MK212 significantly disrupted pup retrieval, pup licking, pup nursing, and nest building in a dose-dependent fashion. At the tested doses, MDL100907 had little effect on various components of rat maternal behavior. Across the 3 days of testing, no apparent sensitization or tolerance associated with repeated administration of MK212 and MDL100907 was found. We concluded that rat maternal performance is critically dependent on 5-HT2C receptors, while the role of 5-HT2A receptors is still inconclusive. Possible behavioral mechanisms of actions of 5-HT2C receptor in maternal behavior are discussed. (C) 2013 Elsevier Inc. All rights reserved.
关键词5-Hydroxytryptamine 2C receptor 5-Hydroxytryptamine 2A receptor Maternal behavior MK212 MDL100907
收录类别SCI
语种英语
WOS记录号WOS:000331501500004
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被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14232
专题中国科学院心理健康重点实验室
作者单位1.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
2.Southwest Univ, Fac Psychol, Chongqing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
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Chen, Weihai,Zhang, Qi,Su, Wenxin,et al. Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2014,117(0):25-33.
APA Chen, Weihai.,Zhang, Qi.,Su, Wenxin.,Zhang, Haorong.,Yang, Yu.,...&Li, Ming.(2014).Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,117(0),25-33.
MLA Chen, Weihai,et al."Effects of 5-hydroxytryptamine 2C receptor agonist MK212 and 2A receptor antagonist MDL100907 on maternal behavior in postpartum female rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 117.0(2014):25-33.
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