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Neural Correlates of Prospective Memory in Individuals With Schizotypal Personality Features
Wang, Ya1; Yang, Tian-xiao1; Su, Li2; Yan, Chao1; Wang, Yi1; Huang, Jia1; Fan, Ming-xia3; Yin, Da-zi3; Jin, Zhen4; Zeng, Ya-wei4; Shum, David H. K.5,6; Gur, Ruben C.7,8; Chan, Raymond C. K.1,9
First AuthorWang, Ya
Contribution Rank1

Objective: Prospective memory (PM) refers to the ability to remember to perform actions in the future. Schizophrenia spectrum disorders show impairments in PM but neural correlates of these impairments remain unclear. The present study aimed to examine brain activation during PM to identify impairments in individuals with schizotypal personality features. Method: Nineteen participants with schizotypal features and 22 healthy controls participated in a functional MRI experiment while performing a PM task. Results: Results showed that the prefrontal cortex (including Brodmann Area [ BA] 10), middle temporal gyrus, and precuneus were activated when performing the PM task compared with baseline. The schizotypal and control groups did not differ in behavioral PM performance. However, participants with schizotypal features showed decreased activations in the inferior and medial frontal lobes (BA 45, and 8). Conclusions: These results confirmed that the PM network involves prefrontal cortex, including BA 10. The lower activation in prefrontal cortex of individuals with schizotypal features when performing a PM task indicates brain activation abnormality. Notably, this abnormality may occur in the absence of any behavioral manifestation. Our findings support the hypothesis of frontal lobe involvement in PM deficits observed in individuals with schizotypal features.

Keywordprospective memory schizotypal personality feature functional imaging
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WOS IDWOS:000335334000007
WoS QuartileQ1
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
2.Univ Cambridge, Dept Psychol, Cambridge, England
3.E China Normal Univ, Dept Phys, Shanghai 200062, Peoples R China
4.Beijing 306 Hosp, MRI Div, Beijing, Peoples R China
5.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Brisbane, Qld 4111, Australia
6.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia
7.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
8.Philadelphia Vet Adm Med Ctr, Philadelphia, PA USA
9.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100864, Peoples R China
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Ya,Yang, Tian-xiao,Su, Li,et al. Neural Correlates of Prospective Memory in Individuals With Schizotypal Personality Features[J]. NEUROPSYCHOLOGY,2014,28(3):373-381.
APA Wang, Ya.,Yang, Tian-xiao.,Su, Li.,Yan, Chao.,Wang, Yi.,...&Chan, Raymond C. K..(2014).Neural Correlates of Prospective Memory in Individuals With Schizotypal Personality Features.NEUROPSYCHOLOGY,28(3),373-381.
MLA Wang, Ya,et al."Neural Correlates of Prospective Memory in Individuals With Schizotypal Personality Features".NEUROPSYCHOLOGY 28.3(2014):373-381.
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