Unraveling the Miswired Connectome: A Developmental Perspective

	Unraveling the Miswired Connectome: A Developmental Perspective
	Di Martino, Adriana 1; Fair, Damien A.2,3,4; Kelly, Clare 1; Satterthwaite, Theodore D.5; Castellanos, F. Xavier 1,6; Thomason, Moriah E.7,8; Craddock, R. Cameron 6,9; Luna, Beatriz 10; Leventhal, Bennett L.11; Zuo, Xi-Nian12,13,14 ; Milham, Michael P.6,9
摘要	The vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.
	2014-09-17
语种	英语
发表期刊	NEURON
ISSN	0896-6273
卷号	83 期号:6 页码:1335-1353
期刊论文类型	Review
收录类别	SCI
WOS记录号	WOS:000342502400019
引用统计	被引频次：234[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14237
专题	中国科学院行为科学重点实验室
作者单位	1.NYU, Langone Med Ctr, Ctr Child Study, Dept Child & Adolescent Psychiat, New York, NY 10016 USA 2.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97329 USA 3.Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97329 USA 4.Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97329 USA 5.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA 6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA 7.Wayne State Univ, Merrill Palmer Skillman Inst Child & Family Dev, Detroit, MI 48202 USA 8.Wayne State Univ, Dept Pediat, Sch Med, Detroit, MI 48201 USA 9.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA 10.Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15261 USA 11.Univ Calif San Francisco, Langley Porter Psychiat Inst, Dept Psychiat, San Francisco, CA 94143 USA 12.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China 13.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China 14.Southwest Univ, Fac Psychol, Chongqing 100101, Peoples R China
推荐引用方式 GB/T 7714	Di Martino, Adriana,Fair, Damien A.,Kelly, Clare,et al. Unraveling the Miswired Connectome: A Developmental Perspective[J]. NEURON,2014,83(6):1335-1353.
APA	Di Martino, Adriana.,Fair, Damien A..,Kelly, Clare.,Satterthwaite, Theodore D..,Castellanos, F. Xavier.,...&Milham, Michael P..(2014).Unraveling the Miswired Connectome: A Developmental Perspective.NEURON,83(6),1335-1353.
MLA	Di Martino, Adriana,et al."Unraveling the Miswired Connectome: A Developmental Perspective".NEURON 83.6(2014):1335-1353.

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