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Unraveling the Miswired Connectome: A Developmental Perspective
Di Martino, Adriana1; Fair, Damien A.2,3,4; Kelly, Clare1; Satterthwaite, Theodore D.5; Castellanos, F. Xavier1,6; Thomason, Moriah E.7,8; Craddock, R. Cameron6,9; Luna, Beatriz10; Leventhal, Bennett L.11; Zuo, Xi-Nian12,13,14; Milham, Michael P.6,9
AbstractThe vast majority of mental illnesses can be conceptualized as developmental disorders of neural interactions within the connectome, or developmental miswiring. The recent maturation of pediatric in vivo brain imaging is bringing the identification of clinically meaningful brain-based biomarkers of developmental disorders within reach. Even more auspicious is the ability to study the evolving connectome throughout life, beginning in utero, which promises to move the field from topological phenomenology to etiological nosology. Here, we scope advances in pediatric imaging of the brain connectome as the field faces the challenge of unraveling developmental miswiring. We highlight promises while also providing a pragmatic review of the many obstacles ahead that must be overcome to significantly impact public health.
Source PublicationNEURON
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WOS IDWOS:000342502400019
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Document Type期刊论文
Affiliation1.NYU, Langone Med Ctr, Ctr Child Study, Dept Child & Adolescent Psychiat, New York, NY 10016 USA
2.Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97329 USA
3.Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97329 USA
4.Oregon Hlth & Sci Univ, Adv Imaging Res Ctr, Portland, OR 97329 USA
5.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
6.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
7.Wayne State Univ, Merrill Palmer Skillman Inst Child & Family Dev, Detroit, MI 48202 USA
8.Wayne State Univ, Dept Pediat, Sch Med, Detroit, MI 48201 USA
9.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
10.Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15261 USA
11.Univ Calif San Francisco, Langley Porter Psychiat Inst, Dept Psychiat, San Francisco, CA 94143 USA
12.Chinese Acad Sci, Key Lab Behav Sci, Beijing 100101, Peoples R China
13.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing 100101, Peoples R China
14.Southwest Univ, Fac Psychol, Chongqing 100101, Peoples R China
Recommended Citation
GB/T 7714
Di Martino, Adriana,Fair, Damien A.,Kelly, Clare,et al. Unraveling the Miswired Connectome: A Developmental Perspective[J]. NEURON,2014,83(6):1335-1353.
APA Di Martino, Adriana.,Fair, Damien A..,Kelly, Clare.,Satterthwaite, Theodore D..,Castellanos, F. Xavier.,...&Milham, Michael P..(2014).Unraveling the Miswired Connectome: A Developmental Perspective.NEURON,83(6),1335-1353.
MLA Di Martino, Adriana,et al."Unraveling the Miswired Connectome: A Developmental Perspective".NEURON 83.6(2014):1335-1353.
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