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Molecular genetic studies of ADHD and its candidate genes: A review
Li, Zhao1,2; Chang, Su-hua1; Zhang, Liu-yan1,2; Gao, Lei1,2; Wang, Jing1
2014-09-30
Source PublicationPSYCHIATRY RESEARCH
ISSN0165-1781
SubtypeReview
Volume219Issue:1Pages:10-24
AbstractAttention-deficit/hyperactivity disorder (ADHD) is a common childhood-onset psychiatric disorder with high heritability. In recent years, numerous molecular genetic studies have been published to investigate susceptibility loci for ADHD. These results brought valuable candidates for further research, but they also presented great challenge for profound understanding of genetic data and general patterns of current molecular genetic studies of ADHD since they are scattered and heterogeneous. In this review, we presented a retrospective review of more than 300 molecular genetic studies for ADHD from two aspects: (1) the main achievements of various studies were summarized, including linkage studies, candidate-gene association studies, genome-wide association studies and genome-wide copy number variation studies, with a special focus on general patterns of study design and common sample features; (2) candidate genes for ADHD have been systematically evaluated in three ways for better utilization. The thorough summary of the achievements from various studies will provide an overview of the research status of molecular genetics studies for ADHD. Meanwhile, the analysis of general patterns and sample characteristics on the basis of these studies, as well as the integrative review of candidate ADHD genes, will propose new clues and directions for future experiment design. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
KeywordAttention-deficit/hyperactivity Disorder Linkage Study Association Study Study Design Sample Characteristics
Indexed BySSCI
Language英语
WOS IDWOS:000339143700002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14241
Collection中国科学院心理健康重点实验室
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Zhao,Chang, Su-hua,Zhang, Liu-yan,et al. Molecular genetic studies of ADHD and its candidate genes: A review[J]. PSYCHIATRY RESEARCH,2014,219(1):10-24.
APA Li, Zhao,Chang, Su-hua,Zhang, Liu-yan,Gao, Lei,&Wang, Jing.(2014).Molecular genetic studies of ADHD and its candidate genes: A review.PSYCHIATRY RESEARCH,219(1),10-24.
MLA Li, Zhao,et al."Molecular genetic studies of ADHD and its candidate genes: A review".PSYCHIATRY RESEARCH 219.1(2014):10-24.
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