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Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors
Hu, L.1,2,3; Cai, M. M.1,2; Xiao, P.1,2; Luo, F.3; Iannetti, G. D.4
2014-08-20
发表期刊JOURNAL OF NEUROSCIENCE
ISSN0270-6474
文章类型Article
卷号34期号:34页码:11439-11451
产权排序3
摘要

Intense radiant heat pulses concomitantly activate A delta-and C-fiber skin nociceptors, and elicit a typical double sensation: an initial A delta-related pricking pain is followed by a C-related prolonged burning sensation. It has been repeatedly reported that C-fiber laser-evoked potentials (C-LEPs) become detectable only when the concomitant activation of A delta-fibers is avoided or reduced. Given that the saliency of the eliciting stimulus is a major determinant of LEPs, one explanation for these observations is that the saliency of the C-input is smaller than that of the preceding A delta-input. However, even if the saliency of the C-input is reduced because of the preceding A delta-input, a C-LEP should still be visible even when preceded by an A delta-LEP response. Here we tested this hypothesis by applying advanced signal processing techniques (peak alignment and time-frequency decomposition) to electroencephalographic data collected in two experiments conducted in 34 and 96 healthy participants. We show that, when using optimal stimulus parameters (delivering >80 stimuli within a small skin territory), C-LEPs can be reliably detected in most participants. Importantly, C-LEPs are observed even when preceded by A delta-LEPs, both in average waveforms and single trials. By providing quantitative information about several response properties of C-LEPs (latency jitter, stimulus-response and perception-response functions, dependency on stimulus repetitions and stimulated area), these results define optimal parameters to record C-LEPs simply and reliably. These findings have important clinical implications for assessing small-fiber function in neuropathies and neuropathic pain.

关键词a Delta-fibers C-fibers Evoked Potentials First Pain Nociception Second Pain
收录类别SCI
语种英语
WOS记录号WOS:000341312600027
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14249
专题中国科学院心理健康重点实验室
作者单位1.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
2.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
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GB/T 7714
Hu, L.,Cai, M. M.,Xiao, P.,et al. Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors[J]. JOURNAL OF NEUROSCIENCE,2014,34(34):11439-11451.
APA Hu, L.,Cai, M. M.,Xiao, P.,Luo, F.,&Iannetti, G. D..(2014).Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors.JOURNAL OF NEUROSCIENCE,34(34),11439-11451.
MLA Hu, L.,et al."Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors".JOURNAL OF NEUROSCIENCE 34.34(2014):11439-11451.
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