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题名:
Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors
作者: Hu Li(胡理)1,2,3; Cai, M. M.1,2; Xiao, P.1,2; Luo, Fei(罗非)3; Iannetti, G. D.4
文章类型: Article
关键词: A delta-fibers ; C-fibers ; evoked potentials ; first pain ; nociception ; second pain
刊名: JOURNAL OF NEUROSCIENCE
ISSN号: 0270-6474
出版日期: 2014-08-20
卷号: 34, 期号:34, 页码:11439-11451
收录类别: SCI
心理所排序: 3
英文摘要:

Intense radiant heat pulses concomitantly activate A delta-and C-fiber skin nociceptors, and elicit a typical double sensation: an initial A delta-related pricking pain is followed by a C-related prolonged burning sensation. It has been repeatedly reported that C-fiber laser-evoked potentials (C-LEPs) become detectable only when the concomitant activation of A delta-fibers is avoided or reduced. Given that the saliency of the eliciting stimulus is a major determinant of LEPs, one explanation for these observations is that the saliency of the C-input is smaller than that of the preceding A delta-input. However, even if the saliency of the C-input is reduced because of the preceding A delta-input, a C-LEP should still be visible even when preceded by an A delta-LEP response. Here we tested this hypothesis by applying advanced signal processing techniques (peak alignment and time-frequency decomposition) to electroencephalographic data collected in two experiments conducted in 34 and 96 healthy participants. We show that, when using optimal stimulus parameters (delivering >80 stimuli within a small skin territory), C-LEPs can be reliably detected in most participants. Importantly, C-LEPs are observed even when preceded by A delta-LEPs, both in average waveforms and single trials. By providing quantitative information about several response properties of C-LEPs (latency jitter, stimulus-response and perception-response functions, dependency on stimulus repetitions and stimulated area), these results define optimal parameters to record C-LEPs simply and reliably. These findings have important clinical implications for assessing small-fiber function in neuropathies and neuropathic pain.

语种: 英语
WOS记录号: WOS:000341312600027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.psych.ac.cn/handle/311026/14249
Appears in Collections:中国科学院心理健康重点实验室_期刊论文

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作者单位: 1.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China
2.Southwest Univ, Sch Psychol, Chongqing, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England

Recommended Citation:
Hu, L.,Cai, M. M.,Xiao, P.,et al. Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors[J]. JOURNAL OF NEUROSCIENCE,2014,34(34):11439-11451.
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