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Connectivity trajectory across lifespan differentiates the precuneus from the default network
Yang, Zhi1,2; Chang, Catie3; Xu, Ting1; Jiang, Lili1; Handwerker, Daniel A.2; Castellanos, F. Xavier4,5; Milham, Michael P.4,6; Bandettini, Peter A.2; Zuo, Xi-Nian1
AbstractThe default network of the human brain has drawn much attention due to its relevance to various brain disorders, cognition, and behavior. However, its functional components and boundaries have not been precisely defined. There is no consensus as to whether the precuneus, a hub in the functional connectome, acts as part of the default network This discrepancy is more critical for brain development and aging studies: it is not clear whether age has a stronger impact on the default network or precuneus, or both. We used Generalized Ranking and Averaging Independent Component Analysis by Reproducibility (gRAICAR) to investigate the lifespan trajectories of intrinsic functional networks. By estimating individual-specific spatial components and aligning them across subjects, gRAICAR measures the spatial variation of component maps across a population without constraining the same components to appear in every subject In a cross-lifespan fMRI dataset (N = 126, 7-85 years old), we observed stronger age dependence in the spatial pattern of a precuneus-dorsal posterior cingulate cortex network compared to the default network, despite the fact that the two networks exhibit considerable spatial overlap and temporal correlation. These results remained even when analyses were restricted to a subpopulation with very similar head motion across age. Our analyses further showed that the two networks tend to merge with increasing age. Post-hoc analyses of functional connectivity confirmed the distinguishable cross-lifespan trajectories between the two networks. Based on these observations, we proposed a dynamic model of cross-lifespan functional segregation and integration between the two networks, suggesting that the precuneus network may have a different functional role than the default network, which declines with age. These findings have implications for understanding the functional roles of the default network, gaining insight into its dynamics throughout life, and guiding interpretation of alterations in brain disorders. Published by Elsevier Inc.
KeywordDefault network Precuneus Independent component analysis Lifespan trajectory Functional connectome gRAICAR
Source PublicationNEUROIMAGE
Indexed BySCI
WOS IDWOS:000332057400005
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Cited Times:86[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Lab Funct Connectome & Dev,Key Lab Behav Sci, Beijing 100101, Peoples R China
2.NIMH, NIH, Lab Brain & Cognit, Sect Funct Imaging Methods, Bethesda, MD 20892 USA
3.Natl Inst Neurol Disorders & Stroke, NIH, Lab Funct & Mol Imaging, Adv MRI Sect, Bethesda, MD 20892 USA
4.Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
5.NYU, Langone Med Ctr, Ctr Child Study, Ctr Neurodev Disorders, New York, NY 10016 USA
6.Child Mind Inst, Ctr Developing Brain, New York, NY 10022 USA
Recommended Citation
GB/T 7714
Yang, Zhi,Chang, Catie,Xu, Ting,et al. Connectivity trajectory across lifespan differentiates the precuneus from the default network[J]. NEUROIMAGE,2014,89(0):45-56.
APA Yang, Zhi.,Chang, Catie.,Xu, Ting.,Jiang, Lili.,Handwerker, Daniel A..,...&Zuo, Xi-Nian.(2014).Connectivity trajectory across lifespan differentiates the precuneus from the default network.NEUROIMAGE,89(0),45-56.
MLA Yang, Zhi,et al."Connectivity trajectory across lifespan differentiates the precuneus from the default network".NEUROIMAGE 89.0(2014):45-56.
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