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Toward Systems Neuroscience in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis of 75 fMRI Studies
Li, Hui-Jie1; Hou, Xiao-Hui1,2; Liu, Han-Hui3; Yue, Chun-Lin4; He, Yong5,6,7; Zuo, Xi-Nian1,7
2015-03-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
文章类型Article
卷号36期号:3页码:1217-1232
摘要Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions in mild cognitive impairment (MCI) and Alzheimer's disease (AD), and few studies investigated the brain network dysfunction from the system level. In this meta-analysis, we aimed to examine brain network dysfunction in MCI and AD. We systematically searched task-based fMRI studies in MCI and AD published between January 1990 and January 2014. Activation likelihood estimation meta-analyses were conducted to compare the significant group differences in brain activation, the significant voxels were overlaid onto seven referenced neuronal cortical networks derived from the resting-state fMRI data of 1,000 healthy participants. Thirty-nine task-based fMRI studies (697 MCI patients and 628 healthy controls) were included in MCI-related meta-analysis while 36 task-based fMRI studies (421 AD patients and 512 healthy controls) were included in AD-related meta-analysis. The meta-analytic results revealed that MCI and AD showed abnormal regional brain activation as well as large-scale brain networks. MCI patients showed hypoactivation in default, frontoparietal, and visual networks relative to healthy controls, whereas AD-related hypoactivation mainly located in visual, default, and ventral attention networks relative to healthy controls. Both MCI-related and AD-related hyperactivation fell in frontoparietal, ventral attention, default, and somatomotor networks relative to healthy controls. MCI and AD presented different pathological while shared similar compensatory large-scale networks in fulfilling the cognitive tasks. These system-level findings are helpful to link the fundamental declines of cognitive tasks to brain networks in MCI and AD. Hum Brain Mapp 36:1217-1232, 2015.(c) 2014 Wiley Periodicals, Inc.
关键词mild cognitive impairment Alzheimer's disease default mode neuronal network fMRI
收录类别SCI
语种英语
WOS记录号WOS:000349612500030
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14261
专题中国科学院行为科学重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.China Youth Univ Polit Studies, Youth Work Dept, Beijing 100089, Peoples R China
4.Soochow Univ, Inst Sports Med, Suzhou 215006, Peoples R China
5.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
6.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
7.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
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Li, Hui-Jie,Hou, Xiao-Hui,Liu, Han-Hui,et al. Toward Systems Neuroscience in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis of 75 fMRI Studies[J]. HUMAN BRAIN MAPPING,2015,36(3):1217-1232.
APA Li, Hui-Jie,Hou, Xiao-Hui,Liu, Han-Hui,Yue, Chun-Lin,He, Yong,&Zuo, Xi-Nian.(2015).Toward Systems Neuroscience in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis of 75 fMRI Studies.HUMAN BRAIN MAPPING,36(3),1217-1232.
MLA Li, Hui-Jie,et al."Toward Systems Neuroscience in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis of 75 fMRI Studies".HUMAN BRAIN MAPPING 36.3(2015):1217-1232.
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