Investigation of Japanese-specific alleles: Most are of Jomon lineage

	Investigation of Japanese-specific alleles: Most are of Jomon lineage
	Yuasa, Isao 1; Umetsu, Kazuo 2; Adachi, Noboru 3; Matsusue, Aya 4; Nakayashiki, Nori 5; Fujihara, Junko 6; Akane, Atsushi 7; Harihara, Shinji 8; Jin, Feng9 ; Ishikawa, Takaki 1
摘要	Japanese-specific alleles are expected to be powerful markers for the differentiation of the Japanese from other people. In this study, three single nucleotide polymorphisms (SNPs) in the GALNT11, H19, and PLA2G12A genes were analyzed in 2396 DNA samples from 25 global populations, and the derived alleles suggested that Japanese-specific alleles exist on autosomes. To identify new Japanese-specific alleles, candidate SNPs obtained from the HapMap database were investigated using 875 DNA samples from nine populations. A total of 67 (nearly) Japanese-specific derived alleles were observed. Of them, 57 showed higher frequencies in the Ryukyuans, living in the southernmost part of the Japanese Archipelago, than in the Wajins living in mainland-Japan, and 43 were also present in Koreans at low frequencies. Jomon skeletons excavated from Hokkaido, the northernmost island of Japan, showed higher frequencies of the three derived alleles in the GALNT11, H19, and PLA2G12A genes than the Ryukyuans, suggesting that most of the 57 derived alleles observed at the high frequencies in the Ryukyuans originated from the Jomon lineage. These novel markers will be useful in the field of forensics. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
关键词	Japanese-specific Geographic distribution Jomon Population-specific Single nucleotide polymorphisms (SNPs)
	2015
语种	英语
发表期刊	LEGAL MEDICINE
ISSN	1344-6223
卷号	17 期号:1 页码:52-55
期刊论文类型	Article
收录类别	SCI
WOS记录号	WOS:000349726800011
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14264
专题	中国科学院心理健康重点实验室
作者单位	1.Tottori Univ, Div Legal Med, Fac Med, Yonago, Tottori 6838503, Japan 2.Yamagata Univ, Sch Med, Dept Forens Med, Yamagata 99023, Japan 3.Univ Yamanashi, Dept Legal Med, Interdisciplinary Grad Sch Med & Engn, Chuo Ku, Yamanashi, Japan 4.Fukuoka Univ, Sch Med, Dept Forens Med, Fukuoka 81401, Japan 5.Iwate Med Univ, Dept Legal Med, Sch Med, Morioka, Iwate, Japan 6.Shimane Univ, Fac Med, Dept Legal Med, Izumo, Shimane, Japan 7.Kansai Med Univ, Dept Legal Med, Moriguchi, Osaka 570, Japan 8.Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Tokyo 113, Japan 9.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Yuasa, Isao,Umetsu, Kazuo,Adachi, Noboru,et al. Investigation of Japanese-specific alleles: Most are of Jomon lineage[J]. LEGAL MEDICINE,2015,17(1):52-55.
APA	Yuasa, Isao.,Umetsu, Kazuo.,Adachi, Noboru.,Matsusue, Aya.,Nakayashiki, Nori.,...&Ishikawa, Takaki.(2015).Investigation of Japanese-specific alleles: Most are of Jomon lineage.LEGAL MEDICINE,17(1),52-55.
MLA	Yuasa, Isao,et al."Investigation of Japanese-specific alleles: Most are of Jomon lineage".LEGAL MEDICINE 17.1(2015):52-55.

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