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Anterior insular cortex is necessary for empathetic pain perception
Gu, Xiaosi; Gao, Zhixian; Wang, Xingchao; Liu, Xun; Knight, Robert T.; Hof, Patrick R.; Fan, Jin; Fan, J (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
2012
Source PublicationBRAIN
ISSN0006-8950
Subtype期刊论文
Volume135Pages:2726-2735
Contribution Rank5
AbstractEmpathy refers to the ability to perceive and share another person's affective state. Much neuroimaging evidence suggests that observing others' suffering and pain elicits activations of the anterior insular and the anterior cingulate cortices associated with subjective empathetic responses in the observer. However, these observations do not provide causal evidence for the respective roles of anterior insular and anterior cingulate cortices in empathetic pain. Therefore, whether these regions are 'necessary' for empathetic pain remains unknown. Herein, we examined the perception of others' pain in patients with anterior insular cortex or anterior cingulate cortex lesions whose locations matched with the anterior insular cortex or anterior cingulate cortex clusters identified by a meta-analysis on neuroimaging studies of empathetic pain perception. Patients with focal anterior insular cortex lesions displayed decreased discrimination accuracy and prolonged reaction time when processing others' pain explicitly and lacked a typical interference effect of empathetic pain on the performance of a pain-irrelevant task. In contrast, these deficits were not observed in patients with anterior cingulate cortex lesions. These findings reveal that only discrete anterior insular cortex lesions, but not anterior cingulate cortex lesions, result in deficits in explicit and implicit pain perception, supporting a critical role of anterior insular cortex in empathetic pain processing. Our findings have implications for a wide range of neuropsychiatric illnesses characterized by prominent deficits in higher-level social functioning.
Keywordanterior cingulate cortex anterior insular cortex empathy meta-analysis necessity
Subject AreaPerception Psychology,physiological Psychology/biological Psychology
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Indexed BySSCI
Language英语
Funding OrganizationNational Institute of Health (NIH) [R21 MH083164, NS21135] ; James S. McDonnell Foundation [22002078] ; Brain and Behavior Research Foundation NARSAD
Project Intro.The National Institute of Health (NIH) (grants R21 MH083164 to J.F. and NS21135 to R. T. K), the James S. McDonnell Foundation (grant 22002078 to P. R. H.), and a Brain and Behavior Research Foundation NARSAD young investigator award (to X.L.).
WOS IDWOS:000308873600014
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Cited Times:81[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14290
Collection中国科学院行为科学重点实验室
Corresponding AuthorFan, J (reprint author), CUNY Queens Coll, Dept Psychol, 65-30 Kissena Blvd, Flushing, NY 11367 USA.
Recommended Citation
GB/T 7714
Gu, Xiaosi,Gao, Zhixian,Wang, Xingchao,et al. Anterior insular cortex is necessary for empathetic pain perception[J]. BRAIN,2012,135:2726-2735.
APA Gu, Xiaosi.,Gao, Zhixian.,Wang, Xingchao.,Liu, Xun.,Knight, Robert T..,...&Fan, J .(2012).Anterior insular cortex is necessary for empathetic pain perception.BRAIN,135,2726-2735.
MLA Gu, Xiaosi,et al."Anterior insular cortex is necessary for empathetic pain perception".BRAIN 135(2012):2726-2735.
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