PSYCH OpenIR  > 中国科学院心理健康重点实验室
Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens
Han, Chunchao; Guo, Jianyou; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
发表期刊INFLAMMATION
ISSN0360-3997
文章类型期刊论文
卷号35期号:3页码:913-919
产权排序2
摘要The purpose of the present study was to investigate the antibacterial and anti-inflammatory activity of Angelica sinensis extract (AE), Sophora flavescens extract (SE), and herb pair A. sinensis and S. flavescens extract (HPE). Endotoxin-induced uveitis (EIU) was induced in rats by a footpad injection of lipopolysaccharide. The anti-inflammatory potential of AE, SE, and HPE in the regulation of nuclear factor kappa B (NF-kappa B), maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. HPE showed strong antibacterial activity at all tested concentrations (1.25, 2.5, and 5 mu g/ml) to Escherichia coli, Staphylococcus aureus, and Shigella Castellani and Chalmers. HPE significantly inhibited EIU-induced upregulation of NF-kappa B activation and the production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, HPE suppressed MDA and infiltration of PMN. The study supports the hypothesis that the anti-pimple and anti-eczema activities of Dangguikushen compound recipe are attributed to herb pairs, A. sinensis and S. flavescens, used in combination.
关键词traditional Chinese herb pairs inflammation Angelica sinensis S. flavescens LPS
学科领域Medical Psychology
URL查看原文
收录类别SCI
语种英语
项目资助者Project of Shandong Province Higher Educational Science and Technology Program [J08LH62] ; NNSF [30800301, 31170992] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Natural Science Foundation of Shandong Province [Y2007C078] ; Major State Basic Research Development Program of China (973 Program) [2007CB512601]
项目简介This project was supported by the Project of Shandong Province Higher Educational Science and Technology Program (J08LH62), NNSF grant (30800301, 31170992), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18, and KSCX2-EW-J-8). This project was also supported by the Natural Science Foundation of Shandong Province (Y2007C078) and Major State Basic Research Development Program of China (973 Program, 2007CB512601).
WOS记录号WOS:000303382400017
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14291
专题中国科学院心理健康重点实验室
通讯作者Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
推荐引用方式
GB/T 7714
Han, Chunchao,Guo, Jianyou,Guo, JY . Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens[J]. INFLAMMATION,2012,35(3):913-919.
APA Han, Chunchao,Guo, Jianyou,&Guo, JY .(2012).Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens.INFLAMMATION,35(3),913-919.
MLA Han, Chunchao,et al."Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens".INFLAMMATION 35.3(2012):913-919.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
WOS000303382400017.p(348KB) 开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Han, Chunchao]的文章
[Guo, Jianyou]的文章
[Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.]的文章
百度学术
百度学术中相似的文章
[Han, Chunchao]的文章
[Guo, Jianyou]的文章
[Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.]的文章
必应学术
必应学术中相似的文章
[Han, Chunchao]的文章
[Guo, Jianyou]的文章
[Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。