Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens

	Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens
	Han, Chunchao; Guo, Jianyou; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
心理所单位排序	2
摘要	The purpose of the present study was to investigate the antibacterial and anti-inflammatory activity of Angelica sinensis extract (AE), Sophora flavescens extract (SE), and herb pair A. sinensis and S. flavescens extract (HPE). Endotoxin-induced uveitis (EIU) was induced in rats by a footpad injection of lipopolysaccharide. The anti-inflammatory potential of AE, SE, and HPE in the regulation of nuclear factor kappa B (NF-kappa B), maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. HPE showed strong antibacterial activity at all tested concentrations (1.25, 2.5, and 5 mu g/ml) to Escherichia coli, Staphylococcus aureus, and Shigella Castellani and Chalmers. HPE significantly inhibited EIU-induced upregulation of NF-kappa B activation and the production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, HPE suppressed MDA and infiltration of PMN. The study supports the hypothesis that the anti-pimple and anti-eczema activities of Dangguikushen compound recipe are attributed to herb pairs, A. sinensis and S. flavescens, used in combination.
关键词	traditional Chinese herb pairs inflammation Angelica sinensis S. flavescens LPS
学科领域	Medical Psychology
	2012
语种	英语
发表期刊	INFLAMMATION
ISSN	0360-3997
卷号	35 期号:3 页码:913-919
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This project was supported by the Project of Shandong Province Higher Educational Science and Technology Program (J08LH62), NNSF grant (30800301, 31170992), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18, and KSCX2-EW-J-8). This project was also supported by the Natural Science Foundation of Shandong Province (Y2007C078) and Major State Basic Research Development Program of China (973 Program, 2007CB512601).
WOS记录号	WOS:000303382400017
资助机构	Project of Shandong Province Higher Educational Science and Technology Program [J08LH62] ; NNSF [30800301, 31170992] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Natural Science Foundation of Shandong Province [Y2007C078] ; Major State Basic Research Development Program of China (973 Program) [2007CB512601]
引用统计	被引频次：40[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14291
专题	中国科学院心理健康重点实验室
通讯作者	Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Han, Chunchao,Guo, Jianyou,Guo, JY . Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens[J]. INFLAMMATION,2012,35(3):913-919.
APA	Han, Chunchao,Guo, Jianyou,&Guo, JY .(2012).Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens.INFLAMMATION,35(3),913-919.
MLA	Han, Chunchao,et al."Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens".INFLAMMATION 35.3(2012):913-919.

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