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Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens
Han, Chunchao; Guo, Jianyou; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2012
Source PublicationINFLAMMATION
ISSN0360-3997
Subtype期刊论文
Volume35Issue:3Pages:913-919
Contribution Rank2
AbstractThe purpose of the present study was to investigate the antibacterial and anti-inflammatory activity of Angelica sinensis extract (AE), Sophora flavescens extract (SE), and herb pair A. sinensis and S. flavescens extract (HPE). Endotoxin-induced uveitis (EIU) was induced in rats by a footpad injection of lipopolysaccharide. The anti-inflammatory potential of AE, SE, and HPE in the regulation of nuclear factor kappa B (NF-kappa B), maleic dialdehyde (MDA), polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. HPE showed strong antibacterial activity at all tested concentrations (1.25, 2.5, and 5 mu g/ml) to Escherichia coli, Staphylococcus aureus, and Shigella Castellani and Chalmers. HPE significantly inhibited EIU-induced upregulation of NF-kappa B activation and the production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, HPE suppressed MDA and infiltration of PMN. The study supports the hypothesis that the anti-pimple and anti-eczema activities of Dangguikushen compound recipe are attributed to herb pairs, A. sinensis and S. flavescens, used in combination.
Keywordtraditional Chinese herb pairs inflammation Angelica sinensis S. flavescens LPS
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationProject of Shandong Province Higher Educational Science and Technology Program [J08LH62] ; NNSF [30800301, 31170992] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Natural Science Foundation of Shandong Province [Y2007C078] ; Major State Basic Research Development Program of China (973 Program) [2007CB512601]
Project Intro.This project was supported by the Project of Shandong Province Higher Educational Science and Technology Program (J08LH62), NNSF grant (30800301, 31170992), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18, and KSCX2-EW-J-8). This project was also supported by the Natural Science Foundation of Shandong Province (Y2007C078) and Major State Basic Research Development Program of China (973 Program, 2007CB512601).
WOS IDWOS:000303382400017
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14291
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Recommended Citation
GB/T 7714
Han, Chunchao,Guo, Jianyou,Guo, JY . Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens[J]. INFLAMMATION,2012,35(3):913-919.
APA Han, Chunchao,Guo, Jianyou,&Guo, JY .(2012).Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens.INFLAMMATION,35(3),913-919.
MLA Han, Chunchao,et al."Antibacterial and Anti-inflammatory Activity of Traditional Chinese Herb Pairs, Angelica sinensis and Sophora flavescens".INFLAMMATION 35.3(2012):913-919.
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