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Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats
Wang, Jie; Liu, Yong-Mei; Cao, Wei; Yao, Kui-Wu; Liu, Zhen-Quan; Guo, Jian-You; Liu, YM (reprint author), China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China.
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AbstractCordymin is a peptide purified from the medicinal mushroom . The present study investigated the effects of Cordymin in prevention of focal cerebral ischemic/reperfusion (IR) injury. The right middle cerebral artery occlusion model was used in the study. The effects of Cordymin on mortality rate, neurobehavior, grip strength, glutathione content, lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na(+)K(+)ATPase activity glutathione S transferase activity and on the regulation of C3 and C4 protein level, polymorphonuclear cells, interleukin-1 beta and tumor necrosis factor-alpha in a rat model were studied respectively. Treatment (orally) of Cordymin significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury. Moreover, Cordymin significantly inhibited infiltration of polymorphonuclear cells and IR-induced up-regulation of the brain production of C3 protein level, interleukin-1 beta and tumor necrosis factor-alpha. Cordymin significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. Our findings suggest that cordymin have a neuroprotective effect in the ischemic brain, which is due to the inhibition of inflammation and increase of antioxidants activity related to lesion pathogenesis. Cordymin can be used as potential preventive agent against cerebral ischemia-reperfusion injury.
KeywordCordymin Cordyceps sinensis Focal cerebral ischemic/reperfusion (IR) injury MCAO
Subject AreaMedical Psychology
2012
Language英语
Source PublicationMETABOLIC BRAIN DISEASE
ISSN0885-7490
Volume27Issue:2Pages:159-165
Subtype期刊论文
URL查看原文
Indexed BySCI
Project Intro.This work was supported by National Natural Science Foundation of China(No. 81173166); China Postdoctoral Science Foundation Special Project(No. 2010030224); China Postdoctoral Science Foundation (No. 20090450546), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018) and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS IDWOS:000303865200007
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Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14292
Collection中国科学院心理健康重点实验室
Corresponding AuthorLiu, YM (reprint author), China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China.
Recommended Citation
GB/T 7714
Wang, Jie,Liu, Yong-Mei,Cao, Wei,et al. Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats[J]. METABOLIC BRAIN DISEASE,2012,27(2):159-165.
APA Wang, Jie.,Liu, Yong-Mei.,Cao, Wei.,Yao, Kui-Wu.,Liu, Zhen-Quan.,...&Liu, YM .(2012).Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats.METABOLIC BRAIN DISEASE,27(2),159-165.
MLA Wang, Jie,et al."Anti-inflammation and antioxidant effect of Cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, in middle cerebral artery occlusion-induced focal cerebral ischemia in rats".METABOLIC BRAIN DISEASE 27.2(2012):159-165.
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