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Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats
Liu, Zhenquan; Li, Pengtao; Zhao, Dan; Tang, Huiling; Guo, Jianyou; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
2011
Source PublicationINFLAMMATION
ISSN0360-3997
Subtype期刊论文
Volume34Issue:6Pages:639-644
Contribution Rank2
AbstractBrain ischemia-reperfusion (IR) triggers a complex series of biochemical events including inflammation. To test the neuroprotective efficacy of Cordyceps sinensis mycelium (CSM) in a rat model of focal cerebral IR, ischemic animals were treated with CSM. They were evaluated at 24 h after reperfusion for neurological deficit score. Furthermore, the mechanism of the anti-inflammatory potential of CSM in the regulation of nuclear factor kappaB, polymorphonuclear cells (PMN), interleukin-1 beta (IL-1 beta), inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-alpha), adhesion molecule (ICAM-1), and cyclooxygenase-2 (COX-2) was determined by ELISA and immunohistochemistry. CSM significantly inhibited IR-induced up-regulation of NF-kappaB activation and the brain production of IL-1 beta, TNF-alpha, iNOS, ICAM-1, and COX-2. Moreover, CSM suppressed infiltration of PMN. The study demonstrates the neuroprotective potential of CSM inhibition through anti-inflammation in a rat model of ischemia-reperfusion.
KeywordCSM inflammation ischemia-reperfusion inflammatory cells inflammatory mediators
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationMinistry of Science and Technology [2009ZX09502-017] ; Key Laboratory of Mental Health, Chinese Academy of Sciences [08CX043004] ; NNSF [30800301] ; Chinese Academy of Sciences [KSCX2-YW-R-254]
Project Intro.This work was supported by the Key New Drugs Innovation project from Ministry of Science and Technology (2009ZX09502-017), the project from Key Laboratory of Mental Health, Chinese Academy of Sciences, Young Scientist project from IPCAS (08CX043004), NNSF grant (30800301), the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254).
WOS IDWOS:000297198400016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14293
Collection中国科学院心理健康重点实验室
Corresponding AuthorGuo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
Recommended Citation
GB/T 7714
Liu, Zhenquan,Li, Pengtao,Zhao, Dan,et al. Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats[J]. INFLAMMATION,2011,34(6):639-644.
APA Liu, Zhenquan,Li, Pengtao,Zhao, Dan,Tang, Huiling,Guo, Jianyou,&Guo, JY .(2011).Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats.INFLAMMATION,34(6),639-644.
MLA Liu, Zhenquan,et al."Anti-inflammation Effects of Cordyceps sinensis Mycelium in Focal Cerebral Ischemic Injury Rats".INFLAMMATION 34.6(2011):639-644.
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