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Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis
Qian, Gui-min; Pan, Guo-Feng; Guo, Jian-You; Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
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摘要The anti-inflammatory and antinociceptive activities of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis, were studied. The effects of cordymin on cytokine levels and total antioxidant activity were analysed. The antinociceptive effects of cordymin in vivo and in vitro were also determined. Cordymin treatment decreased the levels of tumour necrosis factor alpha, interleukin 1 beta and total antioxidant status. Cordymin inhibited the acetic acid-induced abdominal constrictions in mice in a dose-dependent manner. In the hot-plate test, results showed that cordymin significantly inhibited the reaction time to thermal stimuli at 30, 60 and 90 min. In neurolysin inhibition assay, cordymin showed strong activities against neurolysin (IC50 = 0.1 mu M). Our results show that cordymin is a potent anti-inflammatory and analgesic medicine.
关键词cordymin anti-inflammatory antinociceptive TNF-alpha IL-1 beta TAOS neurolysin
学科领域Medical Psychology
2012
语种英语
发表期刊NATURAL PRODUCT RESEARCH
ISSN1061-4036
卷号26期号:24页码:2358-2362
期刊论文类型期刊论文
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收录类别SCI
项目简介This project was supported by NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018), and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8).
WOS记录号WOS:000310608200013
资助机构NNSF [30800301, 31170992] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8]
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被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14294
专题中国科学院心理健康重点实验室
通讯作者Guo, JY (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.
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Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,et al. Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis[J]. NATURAL PRODUCT RESEARCH,2012,26(24):2358-2362.
APA Qian, Gui-min,Pan, Guo-Feng,Guo, Jian-You,&Guo, JY .(2012).Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis.NATURAL PRODUCT RESEARCH,26(24),2358-2362.
MLA Qian, Gui-min,et al."Anti-inflammatory and antinociceptive effects of cordymin, a peptide purified from the medicinal mushroom Cordyceps sinensis".NATURAL PRODUCT RESEARCH 26.24(2012):2358-2362.
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