Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study

	Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study
	Han, Chun-chao; Wei, Hong; Guo, Jianyou; Wei, H (reprint author), Shandong Med Coll, Jinan 250002, Peoples R China.
心理所单位排序	3
摘要	Background: The roots of Sophora flavescens (Leguminosae) have been used in East Asian countries as an herbal medicine and a food ingredient for thousands of years. The aim of the present study was to investigate the effects of S. flavescens fermentation on endotoxin-induced uveitis (EIU) in rats. Methods: EIU was induced in rats via a footpad injection of lipopolysaccharide (LPS). Immediately after the LPS inoculation, fermented and non-fermented extracts of S. flavescens (FSE and NFSE, respectively) were administered orally, and the aqueous humor was collected from both eyes 24 hours later. The anti-inflammatory effects of FSE and NFSE were examined in terms of regulation of nuclear factor kappa B (NF-kappa B) activation and the expression of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), inducible nitric oxide synthase (iNOS), intercellular cell adhesion molecule (ICAM)-1, and cyclooxygenase-2 (COX-2). The regulation of maleic dialdehyde (MDA) levels and polymorphonuclear cell (PMN) infiltration by FSE and NFSE were also examined. Results: Treatment with FSE significantly inhibited LPS-induced increases in IL-1 beta and TNF-alpha production and the expression of iNOS, ICAM-1 and COX-2. Moreover, FSE suppressed LPS-induced NF-kappa B activation, and reduced both MDA levels and infiltration by PMN. Conclusion: These results indicate that solid state fermentation may enhance the anti-inflammatory effects of S. flavescens.
学科领域	Medical Psychology
	2011
语种	英语
发表期刊	BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN	1472-6882
卷号	11
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This study was supported by the Project of Shandong Province Higher Educational Science and Technology Program (J08LH62), NNSF grant (30800301, 31170992), the Key New Drugs Innovation project from Ministry of Science and Technology (2010ZX09102-201-018) and the Knowledge Innovation Program of the Chinese Academy of Sciences (KSCX2-YW-R-254, KSCX2-EW-Q-18 and KSCX2-EW-J-8). This project was also supported by Natural Science Foundation of Shandong Province (Y2007C078).
WOS记录号	WOS:000296962600001
资助机构	Shandong Province Higher Educational Science and Technology [J08LH62] ; NNSF [30800301, 31170992] ; Ministry of Science and Technology [2010ZX09102-201-018] ; Chinese Academy of Sciences [KSCX2-YW-R-254, KSCX2-EW-Q-18, KSCX2-EW-J-8] ; Natural Science Foundation of Shandong Province [Y2007C078]
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14295
专题	中国科学院心理健康重点实验室
通讯作者	Wei, H (reprint author), Shandong Med Coll, Jinan 250002, Peoples R China.
推荐引用方式 GB/T 7714	Han, Chun-chao,Wei, Hong,Guo, Jianyou,et al. Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study[J]. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,2011,11.
APA	Han, Chun-chao,Wei, Hong,Guo, Jianyou,&Wei, H .(2011).Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study.BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE,11.
MLA	Han, Chun-chao,et al."Anti-inflammatory effects of fermented and non-fermented Sophora flavescens: a comparative study".BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 11(2011).

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