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Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80
Ruan, Yeping; Yao, Li; Zhang, Bingbing; Zhang, Shuijuan; Guo, Jianyou; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
2011
发表期刊PEPTIDES
ISSN0027-8424
文章类型期刊论文
卷号32期号:7页码:1526-1529
产权排序2
摘要Neurotoxin-1 (NT) is an analgesic peptide which is endowed an exceptional specificity of action that blocks transmission of the nerve impulse. The aim of this study was to evaluate the potential application of nanoparticles technology as drug carrier system for the nasal delivery of NT. Mice were administered intranasally (i.n.) with NT (NT-P-NP), free NT solution (F-NT) and intravenously (i.v.) with NT (IV-NT) respectively. The NT levels in animal brain and antinociceptive activity of NT were analyzed. The result on brain transport showed that nanoparticles could exert enhanced delivery of NT into the brain significantly after i.n. administration. The results of antinociceptive activity showed that NT-P-NP increased immobility in the open-field test, both phases of formalin test were significantly inhibited by the NT-P-NP and NT-P-NP significantly inhibited the reaction time to thermal stimuli at 60 and 90 min. Both NT-P-NP and IV-NT were able to inhibit constrictions in acetic acid-induced writhing reaction. These data suggest that NT-loaded nanoparticles coated with polysorbate-80 could generate a significant improvement of drug levels in the brain. Intranasal administration of Neurotoxin1 entrapped in nanoparticles coated with polysorbate-80 is an attractive alternative to intravenous administration. (C) 2011 Elsevier Inc. All rights reserved.
关键词Neurotoxin-1 Nanoparticles Polysorbate-80 Antinociceptive properties Nasal delivery
学科领域Medical Psychology
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收录类别SCI
语种英语
项目资助者Nature Sciences Foundation of Zhejiang [Y2101127]
项目简介This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127).
WOS记录号WOS:000293679200023
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14296
专题中国科学院心理健康重点实验室
通讯作者Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
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Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80[J]. PEPTIDES,2011,32(7):1526-1529.
APA Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2011).Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80.PEPTIDES,32(7),1526-1529.
MLA Ruan, Yeping,et al."Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80".PEPTIDES 32.7(2011):1526-1529.
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