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Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80
Ruan, Yeping; Yao, Li; Zhang, Bingbing; Zhang, Shuijuan; Guo, Jianyou; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
2011
Source PublicationPEPTIDES
ISSN0027-8424
Subtype期刊论文
Volume32Issue:7Pages:1526-1529
Contribution Rank2
AbstractNeurotoxin-1 (NT) is an analgesic peptide which is endowed an exceptional specificity of action that blocks transmission of the nerve impulse. The aim of this study was to evaluate the potential application of nanoparticles technology as drug carrier system for the nasal delivery of NT. Mice were administered intranasally (i.n.) with NT (NT-P-NP), free NT solution (F-NT) and intravenously (i.v.) with NT (IV-NT) respectively. The NT levels in animal brain and antinociceptive activity of NT were analyzed. The result on brain transport showed that nanoparticles could exert enhanced delivery of NT into the brain significantly after i.n. administration. The results of antinociceptive activity showed that NT-P-NP increased immobility in the open-field test, both phases of formalin test were significantly inhibited by the NT-P-NP and NT-P-NP significantly inhibited the reaction time to thermal stimuli at 60 and 90 min. Both NT-P-NP and IV-NT were able to inhibit constrictions in acetic acid-induced writhing reaction. These data suggest that NT-loaded nanoparticles coated with polysorbate-80 could generate a significant improvement of drug levels in the brain. Intranasal administration of Neurotoxin1 entrapped in nanoparticles coated with polysorbate-80 is an attractive alternative to intravenous administration. (C) 2011 Elsevier Inc. All rights reserved.
KeywordNeurotoxin-1 Nanoparticles Polysorbate-80 Antinociceptive properties Nasal delivery
Subject AreaMedical Psychology
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Indexed BySCI
Language英语
Funding OrganizationNature Sciences Foundation of Zhejiang [Y2101127]
Project Intro.This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127).
WOS IDWOS:000293679200023
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14296
Collection中国科学院心理健康重点实验室
Corresponding AuthorRuan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
Recommended Citation
GB/T 7714
Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80[J]. PEPTIDES,2011,32(7):1526-1529.
APA Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2011).Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80.PEPTIDES,32(7),1526-1529.
MLA Ruan, Yeping,et al."Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80".PEPTIDES 32.7(2011):1526-1529.
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