Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80

	Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80
	Ruan, Yeping; Yao, Li; Zhang, Bingbing; Zhang, Shuijuan; Guo, Jianyou; Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
心理所单位排序	2
摘要	Neurotoxin-1 (NT) is an analgesic peptide which is endowed an exceptional specificity of action that blocks transmission of the nerve impulse. The aim of this study was to evaluate the potential application of nanoparticles technology as drug carrier system for the nasal delivery of NT. Mice were administered intranasally (i.n.) with NT (NT-P-NP), free NT solution (F-NT) and intravenously (i.v.) with NT (IV-NT) respectively. The NT levels in animal brain and antinociceptive activity of NT were analyzed. The result on brain transport showed that nanoparticles could exert enhanced delivery of NT into the brain significantly after i.n. administration. The results of antinociceptive activity showed that NT-P-NP increased immobility in the open-field test, both phases of formalin test were significantly inhibited by the NT-P-NP and NT-P-NP significantly inhibited the reaction time to thermal stimuli at 60 and 90 min. Both NT-P-NP and IV-NT were able to inhibit constrictions in acetic acid-induced writhing reaction. These data suggest that NT-loaded nanoparticles coated with polysorbate-80 could generate a significant improvement of drug levels in the brain. Intranasal administration of Neurotoxin1 entrapped in nanoparticles coated with polysorbate-80 is an attractive alternative to intravenous administration. (C) 2011 Elsevier Inc. All rights reserved.
关键词	Neurotoxin-1 Nanoparticles Polysorbate-80 Antinociceptive properties Nasal delivery
学科领域	Medical Psychology
	2011
语种	英语
发表期刊	PEPTIDES
ISSN	0027-8424
卷号	32 期号:7 页码:1526-1529
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This project was supported by Nature Sciences Foundation of Zhejiang (Y2101127).
WOS记录号	WOS:000293679200023
资助机构	Nature Sciences Foundation of Zhejiang [Y2101127]
引用统计	被引频次：17[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14296
专题	中国科学院心理健康重点实验室
通讯作者	Ruan, YP (reprint author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Zhejiang, Peoples R China.
推荐引用方式 GB/T 7714	Ruan, Yeping,Yao, Li,Zhang, Bingbing,et al. Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80[J]. PEPTIDES,2011,32(7):1526-1529.
APA	Ruan, Yeping,Yao, Li,Zhang, Bingbing,Zhang, Shuijuan,Guo, Jianyou,&Ruan, YP .(2011).Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80.PEPTIDES,32(7),1526-1529.
MLA	Ruan, Yeping,et al."Antinociceptive properties of nasal delivery of Neurotoxin-loaded nanoparticles coated with polysorbate-80".PEPTIDES 32.7(2011):1526-1529.

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