Binding of bacterial secondary messenger molecule c di-GMP is a STING operation

	Binding of bacterial secondary messenger molecule c di-GMP is a STING operation
	Shaw, Neil; Ouyang, Songying; Liu, Zhi-jie; Liu, ZJ (reprint author), Chinese Acad Sci, Inst Psychol, Natl Lab Biomacromol, Beijing 100101, Peoples R China.
心理所单位排序	2
摘要	Initial skirmishes between the host and pathogen result in spillage of the contents of the bacterial cell. Amongst the spillage, the secondary messenger molecule, cyclic dimeric guanosine monophosphate (c di-GMP), was recently shown to be bound by stimulator of interferon genes (STING). Binding of c di-GMP by STING activates the Tank Binding Kinase (TBK1) mediated signaling cascades that galvanize the body's defenses for elimination of the pathogen. In addition to c di-GMP, STING has also been shown to function in innate immune responses against pathogen associated molecular patterns (PAMPs) originating from the DNA or RNA of pathogens. The pivotal role of STING in host defense is exemplified by the fact that STING(-/-) mice die upon infection by HSV-1. Thus, STING plays an essential role in innate immune responses against pathogens. This opens up an exciting possibility of targeting STING for development of adjuvant therapies to boost the immune defenses against invading microbes. Similarly, STING could be targeted for mitigating the inflammatory responses augmented by the innate immune system. This review summarizes and updates our current understanding of the role of STING in innate immune responses and discusses the future challenges in delineating the mechanism of STING-mediated responses.
关键词	innate immune response adaptor protein dimeric assembly crystal structure c di-GMP
学科领域	Physiological Psychology/biological Psychology
	2013
语种	英语
发表期刊	PROTEIN & CELL
ISSN	1674-800X
卷号	4 期号:2 页码:117-129
期刊论文类型	期刊论文
URL	查看原文
收录类别	SCI
项目简介	This work was supported by the National Natural Science Foundation of China (Grant No. 31070660) and the Ministry of Science and Technology of China (No. 2009DFB30310).
WOS记录号	WOS:000316228300004
资助机构	National Natural Science Foundation of China [31070660] ; Ministry of Science and Technology of China [2009DFB30310]
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/14312
专题	中国科学院心理健康重点实验室
通讯作者	Liu, ZJ (reprint author), Chinese Acad Sci, Inst Psychol, Natl Lab Biomacromol, Beijing 100101, Peoples R China.
推荐引用方式 GB/T 7714	Shaw, Neil,Ouyang, Songying,Liu, Zhi-jie,et al. Binding of bacterial secondary messenger molecule c di-GMP is a STING operation[J]. PROTEIN & CELL,2013,4(2):117-129.
APA	Shaw, Neil,Ouyang, Songying,Liu, Zhi-jie,&Liu, ZJ .(2013).Binding of bacterial secondary messenger molecule c di-GMP is a STING operation.PROTEIN & CELL,4(2),117-129.
MLA	Shaw, Neil,et al."Binding of bacterial secondary messenger molecule c di-GMP is a STING operation".PROTEIN & CELL 4.2(2013):117-129.

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