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CRF受体对五羟色胺系统的调节作用及早期环境因素的影响
Alternative TitleThe Roles of CRF Receptors in the Modulation of Serotoninergic System and the Effects of Early Environmental Factors
原三娜1; 王琼1; 邵枫1; 王玮文1
2013
Source Publication心理科学进展
Correspondent Emailwangww@psych.ac.cn
ISSN1671-3710
Subtype期刊论文
Volume21Issue:6Pages:982-989
Contribution Rank1
Abstract早期环境因素持续影响脑与行为的发展,增加个体成年后应激相关精神疾病患病的易感性。应激反应的中枢启动因子促肾上腺皮质激素释放因子(corticotropin-releasing factor,CRF)通过两种受体CRF1和CRF2调节中缝背核(dorsal raphe nucleus,DRN)-五羟色胺(serotonin,5-HT)系统,后者已被证实在应激相关情绪疾患发病和治疗过程中发挥重要作用。已知CRF受体以相互影响相互拮抗的方式动态调节DRN-5-HT系统,提示这两种受体相对作用的调节对于协调复杂环境中DRN-5-HT系统的应激反应过程起着关键性作用。早期环境因素和遗传因素交互作用导致CRF受体的分布和反应性持续改变并造成DRN-5-HT系统反应异常,可能是导致应激反应和精神疾病易感性个体差异的重要神经基础。
Other AbstractEarly environmental factors had long-term effects on the development of brain and behaviors, and led to a variety of psychopathological changes. It is well known that the dorsal raphe nucleus (DRN)-serotonin (5-HT) system is implicated in the onset and treatment of stress-related psychiatric disorders. Corticotropin-releasing factor (CRF) modulates activity of this system during stress via activation of two receptors: CRF1 and CRF2. CRF1 and CRF2 mediated inhibition and excitation of the DRN-5-HT system respectively. Therefore, the regulation of the relative contribution of the two CRF receptors to brain CRF pathways may be essential in coordinating 5-HTergic responses to stress. The early environmental factors (e.g. stress) induced long-term even lifetime changes in the distribution and reactivity of CRF receptors, and the DRN-5-HT system response to further stressful stimuli, which might be involved in the individual differences of susceptibility to stress-related psychiatric disorders.
Keyword促肾上腺皮质激素释放激素 早期环境因素 中缝背核 五羟色胺
Subject Area生理心理学/生物心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家自然科学基金项目(91132728),中国科学院知识创新项目(KSCX2-EW-J-8)N中国科学院心理健康重点实验室、中国科学院心理研究所资助.
CSCD IDCSCD:4861690
Citation statistics
Cited Times:2[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14370
Collection中国科学院心理健康重点实验室
Corresponding Author王玮文
Affiliation1.中国科学院心理健康重点实验室
2.中国科学院心理研究所
3.中国科学院大学
4.北京大学心理学系
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
原三娜,王琼,邵枫,等. CRF受体对五羟色胺系统的调节作用及早期环境因素的影响[J]. 心理科学进展,2013,21(6):982-989.
APA 原三娜,王琼,邵枫,&王玮文.(2013).CRF受体对五羟色胺系统的调节作用及早期环境因素的影响.心理科学进展,21(6),982-989.
MLA 原三娜,et al."CRF受体对五羟色胺系统的调节作用及早期环境因素的影响".心理科学进展 21.6(2013):982-989.
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