Institutional Repository of Key Laboratory of Mental Health, CAS
| 肠脑健康状况问卷的初步编制及信效度检验 | |
| Alternative Title | Antidepressive effects of petroleum ether extract from Ranae Oviductu and its possible mechanism |
段云峰 ; 吴晓丽; 金锋
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| Correspondent Email | jinfeng@psych.ac.cn |
| Contribution Rank | 2 |
| Abstract | 目的编制一份测量肠脑健康状况的问卷并检验其信效度。方法经查阅文献和访谈形成含31项的预测问卷;分别对180名和479名被试进行项目分析和探索性因素分析以及信效度检验,选状态-特质焦虑问卷、自评抑郁量表和阿森斯失眠量表为效标。结果项目分析和探索性因素分析表明包含3个维度:肠道状态、饮食习惯和排便情况,21个项目的肠脑健康状况问卷,共解释了54.7%的变异;信度分析显示各维度信度系数在0.64~0.79之间,重测信度在0.70~0.78之间;效度分析表明各维度能反映总问卷所要测查的内容;各维度与总分间存在显著相关(r=0.488~0.798,P<0.01)。结论初步编制的肠脑健康状况问卷具有良好的信效度,可用于肠脑健康状况的相关研究。 |
| Other Abstract | Objective To study the antidepressive effect of the petroleum ether extract from Ranae Oviductus （PERO） on chronic mild stress depressive rat model and its mechanism. Methods The rats were divided into control, model, Fluoxetine （10 mg/kg, positive control）, and different doses （30, 100, and 300 mg/kg） of PERO groups. The rats in PERO groups were administered once daily for 21 d, while the rats in the control and model groups were administered with equivalent normal saline. After 1 h for the rats in PERO and model groups and 0.5 h for the rats in Fluoxetine group of the last administration, the chronic unpredictable mild stress for 21 d was used to induce the depression in rats. The body weight was measured and the depressive-like behaviors were evaluated by the open-field test and sucrose preference test. Then the corticosterone level in the rat plasma was detected by enzyme-linked immunosorbent assay （ELISA） and the brain-derived neurotrophic factor （BDNF） protein levels in the hippocampus were measured by Western blotting analysis. Results Compared with the control group, the body weight, sucrose preference, and motion distance in open-field test of rats were decreased, the corticosterone level in plasma was increased, and the BDNF level in hippocampus was decreased. Compared with the model group, PERO treatment alleviated the body weight decreasing, increased the sucrose preference and motion distance, reduced the corticosterone level in the plasma of rats, and increased the BDNF level in hippocampus of rats. Conclusion The antidepressive effect of PERO is likely mediated by modulating the fimction of hypothalamic-pituitary-adrenalaxis and increasing the expression of BDNF in brain tissues. |
| Keyword | 心理测量 肠脑健康状况 因素分析 信效度 心理评估 |
| Subject Area | 心理测量 |
| 2013 | |
| Language | 中文 |
| Source Publication | 中国健康心理学杂志
 |
| ISSN | 1005-1252 |
| Volume | 44Issue:12Pages:1823-1826 |
| Subtype | 期刊论文 |
| URL | 查看原文 |
| Indexed By | CSCD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.psych.ac.cn/handle/311026/14429 |
| Collection | 中国科学院心理健康重点实验室 |
| Corresponding Author | 金锋 |
| Affiliation | 中国科学院心理健康重点实验室 |
| First Author Affilication | Key Laboratory of Mental Health, CAS |
| Corresponding Author Affilication | Key Laboratory of Mental Health, CAS |
| Recommended Citation GB/T 7714 | 段云峰,吴晓丽,金锋. 肠脑健康状况问卷的初步编制及信效度检验[J]. 中国健康心理学杂志,2013,44(12):1823-1826. |
| APA | 段云峰,吴晓丽,&金锋.(2013).肠脑健康状况问卷的初步编制及信效度检验.中国健康心理学杂志,44(12),1823-1826. |
| MLA | 段云峰,et al."肠脑健康状况问卷的初步编制及信效度检验".中国健康心理学杂志 44.12(2013):1823-1826. |
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| 肠脑健康状况问卷的初步编制及信效度检验_（209KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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