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大脑皮层-背侧纹状体通路在吗啡强迫性觅药和用药行为中的作用
Alternative TitleThe Role of the Cortex-Dorsal Striatum Pathway in Morphine-Induced Compulsive Drug Seeking and Taking Behaviors
白云静; 郑希耕
2011
Source Publication心理科学进展
Correspondent Emailbaiyj@psych.ac.cn
ISSN1671-3710
Subtype期刊论文
Volume19Issue:5Pages:633-644
Contribution Rank1
Abstract药物成瘾是以强迫性觅药和用药行为为核心特征的慢性脑疾病。从初始用药到强迫性用药是成瘾者的觅药行为从目标导向性向习惯化发展的过程。强迫性觅药和用药行为是依赖于背外侧纹状体的习惯化行为,同时前额叶皮层-背内侧纹状体通路对行为的控制减弱,导致感觉运动皮层-背外侧纹状体通路对行为的控制持续占主导地位,是成瘾行为具有强迫性特征的重要神经基础。本项目围绕这一重要问题展开研究,在建立具有成瘾特征的动物模型的基础上,采用行为学、行为药理学和组织形态学等方法揭示皮层-纹状体通路在强迫性觅药和用药行为中的作用。研究结果有望为进一步寻找该神经网络参与成瘾行为的分子机制提供重要线索。
Other AbstractDrug addiction is a chronic brain disease characterized by compulsive drug seeking and taking behaviors. From initially go-directed drug use to compulsive drug taking, the drug-seeking behavior in addicts becomes more and more habitual. Compulsive drug seeking and taking behaviors are habitual behaviors depending on dorsolateral striatum, and the impaired function of the prefrontal cortex-dorsomedial striatum pathway, which leads to persistent control of behavior by sensorimotor cortex-dorsolateral striatum pathway, is an important neural mechanism underlying compulsive addicted behaviors. The study will establish the animal model of drug addiction and adopt behavioral, behavioral pharmacological and morphological techniques to discover the role of the cortex-striatum pathway in compulsive drug seeking and taking behaviors. The results may shed light on the possible molecular mechanisms involved in drug addiction.
Keyword强迫性觅药行为 背外侧纹状体 前额叶皮层 前额叶皮层-背内侧纹状体通路
Subject Area医学心理学
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Indexed ByCSCD
Language中文
Funding Organization国家自然科学基金青年项目资助(31000463).
CSCD IDCSCD:4210485
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14477
Collection健康与遗传心理学研究室
Corresponding Author白云静
Affiliation中国科学院心理研究所健康与遗传心理学研究室
Recommended Citation
GB/T 7714
白云静,郑希耕. 大脑皮层-背侧纹状体通路在吗啡强迫性觅药和用药行为中的作用[J]. 心理科学进展,2011,19(5):633-644.
APA 白云静,&郑希耕.(2011).大脑皮层-背侧纹状体通路在吗啡强迫性觅药和用药行为中的作用.心理科学进展,19(5),633-644.
MLA 白云静,et al."大脑皮层-背侧纹状体通路在吗啡强迫性觅药和用药行为中的作用".心理科学进展 19.5(2011):633-644.
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