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胆囊收缩素在焦虑相关障碍中的作用探讨
Alternative TitleRole of Cholecystokinin in Anxiety-related Disorder
郑伦; 郑希耕
2013
Source Publication中国全科医学
Correspondent Emailzhengxg@psych.ac.cn
ISSN1007-9572
Subtype期刊论文
Volume16Issue:17Pages:1543-1547
Contribution Rank1
Abstract

胆囊收缩素(CCK)是广泛分布于中枢神经系统的神经肽,在焦虑相关障碍中发挥重要的调控作用。CCK与多巴胺(DA)、γ-氨基丁酸(GABA)等经典神经递质在边缘系统共存。在CCK的两种受体亚型中,CCK2受体在焦虑行为的控制中起重要作用,激活CCK2受体具有致焦虑作用,封闭CCK2受体则具有抗焦虑作用。CCK2受体拮抗剂在焦虑障碍的临床治疗中具有重要的应用前景。

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Cholecystokinin (CCK) is an abundant and widely distributed neuropeptide that plays a modulatory role in anxiety -related disorder. CCK is co -localized in cell bodies and terminals with many other neurotransmitters in limbic system, such as dopamine (DA) and -γ -aminobutyric acid (GABA) . Of the two CCK receptor subtypes, .CCK2 receptors are most im- plicated in the control of anxiety - related behavior. The activation of the CCK2 receptor causes anxiogenic effects while the block- ade of it has anxiolytic effect. CCK2 receptor antagonist may provide important therapeutic strategies to treat anxiety - related disor- der.

Keyword胆囊收缩素 焦虑相关障碍
Subject Area情绪心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家自然科学基金项目(30971057) ; 中科院知识创新工作重要方向项目(KSCX2-EW-J-8)
CSCD IDCSCD:4850189
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14493
Collection中国科学院心理健康重点实验室
Corresponding Author郑希耕
Affiliation中国科学院心理健康重点实验室
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
郑伦,郑希耕. 胆囊收缩素在焦虑相关障碍中的作用探讨[J]. 中国全科医学,2013,16(17):1543-1547.
APA 郑伦,&郑希耕.(2013).胆囊收缩素在焦虑相关障碍中的作用探讨.中国全科医学,16(17),1543-1547.
MLA 郑伦,et al."胆囊收缩素在焦虑相关障碍中的作用探讨".中国全科医学 16.17(2013):1543-1547.
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