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Alternative TitleGenetic and Neurobiological Mechanisms of Non-drug Addictions
李梦姣1; 陈杰1; 李新影1
Source Publication心理科学进展
Contribution Rank1
Other AbstractNon-drug addictions, which are also referred to as behavioral addictions, or non-su0stance- related addictions, include disorders such as pathological gambling, internet addiction, shopping addiction, cyber game addiction, sex addiction and binge-eating. These disorders are characterized by craving for certain behaviors, impaired impulse controls, tolerance, withdraw and high relapse rates. High phenomenological similarities and comorbidity between non-drug addictions and drug addictions indicate that these two types of addictions may share some common etiological mechanisms. Family and twin studies revealed moderate to large genetic influence on non-drug addictions, such as binge-eating and pathological gambling in male. Molecular genetic studies found that serotonin (5-HT) system genes, dopamine receptor genes and MAOA genes might be involved in the etiology of non-drug addictions. Furthermore, brain activities of non-drug addicts were different from those of the control groups, especially in the neural pathway for reward, cue processing and impulsive control. Investigating the underlying genetic and neurobiological mechanisms of non-drug addictions has both theoretical and practical implications. Studies from multiple perspectives are needed to illustrate the similarities and heterogeneity of the non-drug addictions and drug addictions.
Keyword非药物成瘾 遗传 神经机制
Subject Area医学心理学
Indexed ByCSCD
Funding Organization国家自然科学基金项目(31170993,91132728) ; 中国科学院知识创新工程重要方向项目(KSCX2.EW-J_8)和中国科学院心理研究所青年基金(YOCX351S01)资助.
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Document Type期刊论文
Corresponding Author李新影
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
李梦姣,陈杰,李新影. 非药物成瘾的遗传学和神经生物学机制研究述评[J]. 心理科学进展,2012,20(10):1623-1632.
APA 李梦姣,陈杰,&李新影.(2012).非药物成瘾的遗传学和神经生物学机制研究述评.心理科学进展,20(10),1623-1632.
MLA 李梦姣,et al."非药物成瘾的遗传学和神经生物学机制研究述评".心理科学进展 20.10(2012):1623-1632.
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