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高良姜油对胃溃疡小鼠模型血清NO、SOD及MDA的影响
Alternative TitleEffect of oils in alpinia officinarum hance on serum NO, SOD, MDA in gastrelcosis mice model
王海燕1; 刘亚明1; 李海燕1; 冯前进1; 郭建友1; 牛欣1
2011
Source Publication中华中医药杂志
Correspondent Emailliuyaming66@yahoo.com.cn
ISSN1673-1727
Subtype期刊论文
Volume26Issue:7Pages:1640-1642
Contribution Rank4
Abstract目的:研究高良姜油对胃溃疡小鼠模型血清一氧化氮(NO)、超氧化物歧化酶(SOD)及丙二醛(MDA)的影响。方法:ICR小鼠随机分成8组:正常组、模型组、山莨菪碱片组(0.005g/kg)、奥美拉唑组(0.014g/kg)、良附丸组(2g/kg),高良姜油高、中、低剂量组(8、4、2mL/kg),预防给药6d后,采用利血平致胃溃疡小鼠模型,测定小鼠血清NO含量、SOD活性及MDA含量。结果:与模型组相比,高良姜油的高、中剂量组、良附丸组、奥美拉唑组、山莨菪碱组均能增加利血平致胃溃疡小鼠模型血清NO含量和SOD活性,降低MDA含量(P<0.05,P<0.01)。结论:高良姜油抗胃溃疡作用机制可能与其抗氧化、舒张血管作用有关。; Objective: To explore effects of Oils in alpinia officinarum hance (OAOH)on NO, SOD, MDA of gastrelcosis mice model .Method: ICR mice were randomly divided into 8 groups:control group, modle group, racanisodimine group ( 0.005g/kg ) , Omeprazole group(0.014g/kg),liangfu pills group ( 2g/kg ) , OAOH high dosage group, OAOH middle dosage group, OAOH low dosage group ( 8, 4, 2mL/kg ) . The gastrelcosis mice model was induced by reserpine,which was then given drugs for 6 days. Nitric oxide(NO) content,superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in mice serum were determined.Result: Compared with the model group: OAOH (H,M), liangfu pills, Omeprazole group ,racanisodimine group obviously ncreased the content of NO and active of SOD in serum, decreased the content of MDA in serum ( P〈0.05, P〈0.01 ) . Conclusion: OAOH treats gastrelcosis by eliminating free radical and improving local blood circulation of the ulcer.
Keyword高良姜油 胃溃疡 一氧化氮 超氧化物歧化酶 丙二醛 小鼠
Subject Area生理心理学/生物心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization基金资助:教育部自选课题(No.2011JYB22-JS003)
CSCD IDCSCD:4235056
Citation statistics
Cited Times:4[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14567
Collection健康与遗传心理学研究室
Corresponding Author刘亚明
Affiliation1.北京中医药大学基础医学院
2.湖北中医药大学基础医学院
3.山西中医学院科研处
4.中国科学院心理研究所
Recommended Citation
GB/T 7714
王海燕,刘亚明,李海燕,等. 高良姜油对胃溃疡小鼠模型血清NO、SOD及MDA的影响[J]. 中华中医药杂志,2011,26(7):1640-1642.
APA 王海燕,刘亚明,李海燕,冯前进,郭建友,&牛欣.(2011).高良姜油对胃溃疡小鼠模型血清NO、SOD及MDA的影响.中华中医药杂志,26(7),1640-1642.
MLA 王海燕,et al."高良姜油对胃溃疡小鼠模型血清NO、SOD及MDA的影响".中华中医药杂志 26.7(2011):1640-1642.
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