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高良姜油抗实验性胃溃疡作用及其机制研究
Alternative TitleEffects of valtrate on anxiety models in rats and its possible mechanisms
王海燕1; 刘亚明1; 牛欣1; 冯前进1; 李海燕1; 郭建友1
2011
Source Publication中国中西医结合消化杂志
Correspondent Emailliuyaming66@yahoo.com.cn
ISSN1671-038X
Subtype期刊论文
Volume27Issue:2Pages:71-74
Contribution Rank2
Abstract[目的]研究高良姜油抗胃溃疡(GU)的作用及其机制。[方法]ICR小鼠随机分成7组,分别为:正常对照组,模型组,奥美拉唑组(0.014 g/kg),良附丸组(2 g/kg),高良姜油高、中、低剂量(8、42、ml/kg)组,预防给药6d后,采用利血平致GU小鼠模型,收集小鼠胃液,测定胃液量、总酸度、胃蛋白酶活性及血清一氧化氮(NO)、超氧化物歧化酶(SOD)及丙二醛(MDA)水平。[结果]与模型组相比,高良姜油高、中剂量组,良附丸组,奥美拉唑组均能抑制利血平致GU小鼠模型胃液量、总酸度及胃蛋白酶活性,且能增加血清NO水平和SOD活性,降低MDA水平;但中剂量组胃蛋白酶活性变化无统计学意义。[结论]高良姜油抗GU作用机制可能与其抑酸、抗氧化、增强保护因子有关;高良姜油高剂量抗氧化与增加血清NO水平的作用与良附丸相当。
Other AbstractAim To study the anxiolytic effects of valtrate on anxiety models and investigate the related mechanisms.Methods The elevated plus-maze test(EPM) and open field were used as in vivo model,and the anxiolytic activities of valtrate were investigated.Then the corticosterone levels in the rat plasma were measured by enzyme-linked immunosorbent assay(ELISA).Result The valtrate(10 mg·kg-1,ig) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the elevated plus maze and the number of central entries in the open filed.ELISA showed that valtrate significantly reduced the corticosterone level in the rat plasma.Conclusion The valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis(HPAA).
Keyword胃溃疡 高良姜油 一氧化氮 超氧化物歧化酶 丙二醛
Subject Area医学心理学
URL查看原文
Language中文
Funding Organization国家“重大新药创制”科技重大专项(No2009ZX09103-381) ; 中国科学院基础前沿性项目(NoKSCX2-EW-J-8)
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14569
Collection中国科学院心理健康重点实验室
Corresponding Author刘亚明
Affiliation1.北京中医药大学基础医学院
2.湖北中医药大学基础医学院
3.山西中医学院方剂教研室
4.中国科学院心理研究所心理健康重点实验室
Recommended Citation
GB/T 7714
王海燕,刘亚明,牛欣,等. 高良姜油抗实验性胃溃疡作用及其机制研究[J]. 中国中西医结合消化杂志,2011,27(2):71-74.
APA 王海燕,刘亚明,牛欣,冯前进,李海燕,&郭建友.(2011).高良姜油抗实验性胃溃疡作用及其机制研究.中国中西医结合消化杂志,27(2),71-74.
MLA 王海燕,et al."高良姜油抗实验性胃溃疡作用及其机制研究".中国中西医结合消化杂志 27.2(2011):71-74.
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