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交通事故幸存者创伤后应激障碍的流行情况及预测因素分析
其他题名Prevalence and predictive factors of post-traumatic stress disorder among survivors of traffic accidents
李秀丽1; 车力凡1; 孙鲁毅1; 王力1
2012
发表期刊社区医学杂志
ISSN1672-4208
文章类型期刊论文
卷号10期号:17页码:001-004
产权排序2
摘要目的了解交通事故幸存者创伤后应激障碍(post traumatic stress disorder,PTSD)的流行情况,并分析相关的预测因素。方法选择2010年10月—2011年5月206例交通事故幸存者,其中,男168例,女38例,年龄(39.8±12.5)岁。采用17项PTSD检测表——特定事件版(PTSD checklist-specific stressor version,PCL-S)进行评估。结果 206例交通事故幸存者中共有51例为可能的PTSD患者,发生率为24.8%;PTSD症状比较女性较男性严重,男性PCL-S得分(26.90±7.70)分,女性(31.46±8.87)分,男女比较差异有统计学意义(P<0.05),已婚者较单身者严重,已婚PCL-S得分(28.72±8.07)分,单身(23.00±5.47)分,二者比较差异有统计学意义(P; Background:There is increasing interest in the role of brain-derived neurotrophic factor(BDNF) in the onset and course of schizophrenia,but there are conflicting reports about serum levels of BDNF in patients with schizophrenia.Aim:Conduct a meta-analysis combining studies from China and other countries that have evaluated the relationship of serum BDNF levels to schizophrenia.Methods:We used Cochrane methodology and RevMan 5.1 software to identify and pool the results of studies.Electronic searches of western and Chinese registries and follow-up assessment of references located 268 potential articles.Twenty-five articles(20 in English and 5 in Chinese) published before December 2011 that used case-control methods,included patients with schizophrenia who had no concurrent disorders,and used ELISA technology to assess serum BDNF were included in the analysis.The main outcome was the pooled standardized mean difference(SMD) between cases and controls.The quality of the studies was independently assessed by two raters using the GRADE system.The heterogeneity,sensitivity and potential publication bias of the studies was evaluated using RevMan.Results:The pooled sample included 1663 patients with schizophrenia and 1355 controls.Fifteen of the included studies were rated as ‘poor quality’ and 10 were rated as‘very poor quality’.The results of the studies were quite heterogenous(I 2 =95%) but subgroup analyses found that the heterogeneity was not related to country of origin,sample size,age,gender,prior use of antipsychotic medication,or study quality.The pooled SMD(computed using a random-effect model because of study heterogeneity) was-0.74(95% CI,-0.99~-0.50;Z=5.99,p0.001).Sensitivity analysis found that the result was stable and there was no evidence of publication bias.Conclusion:Despite the robust statistical findings of lower serum BDNF in patients with schizophrenia than in controls,given the low quality of the available studies and the substantial heterogeneity between studies,the evidence of lower serum BDNF in patients with schizophrenia must be considered‘weak’.The potential use of serum BDNF as a biomarker for schizophrenia must wait until higher-quality prospective studies that follow patients over time and that use uniform selection and monitoring procedures confirm these preliminary results.
关键词创伤后应激障碍 交通事故 流行情况 预测因素
学科领域创伤心理学
URL查看原文
语种中文
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/14676
专题中国科学院心理健康重点实验室
通讯作者李秀丽
作者单位1.潍坊医学院青州临床学院心理科
2.中国科学院心理研究所心理健康重点实验室
推荐引用方式
GB/T 7714
李秀丽,车力凡,孙鲁毅,等. 交通事故幸存者创伤后应激障碍的流行情况及预测因素分析[J]. 社区医学杂志,2012,10(17):001-004.
APA 李秀丽,车力凡,孙鲁毅,&王力.(2012).交通事故幸存者创伤后应激障碍的流行情况及预测因素分析.社区医学杂志,10(17),001-004.
MLA 李秀丽,et al."交通事故幸存者创伤后应激障碍的流行情况及预测因素分析".社区医学杂志 10.17(2012):001-004.
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