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内感受对成瘾行为的诱导及其岛叶的调控机制
Alternative TitleThe Role of Interoception and Insular Cortex in Addiction
李春禄1; 朱宁1; 李勇辉1; 孟肖路1; 高军1; 隋南1
2013
Source Publication生物化学与生物物理进展
Correspondent Emailsuin@psych.ac.cn
ISSN1000-3282
Subtype期刊论文
Volume40Issue:1Pages:15-21
Contribution Rank1
Abstract内感受是机体对自身生理状态的感觉.近年来,越来越多的研究证据表明,内感受可以调控成瘾行为,岛叶是其发挥作用的重要神经基础之一.目前,对岛叶作用机制的研究正受到高度重视.本文从岛叶的基本结构和功能出发,结合近几年来岛叶调控成瘾行为、行为抑制以及情感决策的重要发现,讨论岛叶在成瘾发生及发展过程中的可能作用及其机制,并根据已有的实验证据,试图提出较为合理的研究展望,以推动相关神经环路和神经化学机制研究的深入.
Other AbstractInteroception is the sense of the physiological condition of the body.Recent studies suggested that interoception is involved in drug addiction and insular cortex is a key anatomical position.The neural mechanisms underlying such phenomena attract growing attention.In an effort to develop working hypotheses for future investigation,the article first reviewed the evidence of interoceptive regulation of addiction,and subsequently presented human and animal data that suggest a central role of the insular cortex in mediating interoception and addiction.On this basis,we proposed potential neurobiological mechanisms through which insular cortex may mediate drug addiction.Further,possible functional roles of neurotransmitters in the insular cortex are discussed in the context of drug addiction.
Keyword内感受 岛叶 成瘾
Subject Area医学心理学
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Indexed ByCSCD ; SCI
Language中文
Funding Organization国家自然科学基金(31070911,31170988) ; 国家重点基础研究发展计划(973)(2009CB522002)资助项目~~
CSCD IDCSCD:4738019
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14760
Collection中国科学院心理健康重点实验室
Corresponding Author隋南
Affiliation1.中国科学院心理研究所
2.中国科学院心理健康重点实验室
3.中国科学院大学
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
李春禄,朱宁,李勇辉,等. 内感受对成瘾行为的诱导及其岛叶的调控机制[J]. 生物化学与生物物理进展,2013,40(1):15-21.
APA 李春禄,朱宁,李勇辉,孟肖路,高军,&隋南.(2013).内感受对成瘾行为的诱导及其岛叶的调控机制.生物化学与生物物理进展,40(1),15-21.
MLA 李春禄,et al."内感受对成瘾行为的诱导及其岛叶的调控机制".生物化学与生物物理进展 40.1(2013):15-21.
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