PSYCH OpenIR  > 中国科学院心理健康重点实验室
Alternative TitleCharacteristics of Associative Memory Deficits in Amnestic Mild Cognitive Impairment
王鹏云1; 李娟1; 李会杰1; 李冰1; 李欣1; 周婷1
First Author王鹏云
Contribution Rank1


Other Abstract

Amnestic mild cognitive impairment (aMCI) patients show impairment in both item and associative memory. The current study administered the widely used associative and item memory tests from the Clinical Memory Scale to investigate whether aMCI patients are more impaired in associative memory than item memory. In addition, we aimed to analyze an associative memory test (the paired-associate learning test) in order to investigate in detail the nature of associative memory impairment in aMCI patients. Twenty-five individuals with aMCI and 28 healthy controls took part in the study. Two associative memory tests (paired-associate learning test and associative recall), two item memory tests (free recall of pictures and recognition of meaningless figures), and a set of neurocognitive tests were administered to the participants, aMCI patients performed significantly worse than healthy older adults in both associative memory tests, even when controlling for impairment in the item memory tests. In addition, ROC curve analysis indicated that discriminative power was higher in associative than in item memory tests. Further, the results of the paired-associate learning test indicated that, compared to normal older adults, aMCI patients showed more deficits in remembering the easy word pairs, relative to the difficult word pairs. Our results confirm that aMCI patients demonstrate greater deficits in associative memory than in item memory. In addition to the impairment in creating memory links between items, aMCI patients may have deficits in using the semantic information presented by the items. The associative memory tests showed higher discriminative power than item memory tests in the identification of aMCI patients. Including associative memory testing in future neurocognitive assessment protocols could be helpful to improve the "hit rate" of aMCI detection.

Keyword轻度认知损伤 联系记忆 项目记忆
Subject Area医学心理学
Source Publication生物化学与生物物理进展
Indexed BySCI ; CSCD
Citation statistics
Document Type期刊论文
Corresponding Author李娟
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
王鹏云,李娟,李会杰,等. 轻度认知损伤患者的联系记忆损伤特征[J]. 生物化学与生物物理进展,2013,40(12):1247-1255.
APA 王鹏云,李娟,李会杰,李冰,李欣,&周婷.(2013).轻度认知损伤患者的联系记忆损伤特征.生物化学与生物物理进展,40(12),1247-1255.
MLA 王鹏云,et al."轻度认知损伤患者的联系记忆损伤特征".生物化学与生物物理进展 40.12(2013):1247-1255.
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