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Alternative TitleNeuropsychological Impairment Characteristics of MCI and Its Early Detection and Intervention: Prevent and Delay The Onset of AD
李娟; 喻婧; 牛亚南
Source Publication生物化学与生物物理进展
Contribution Rank1
Abstract轻度认知障碍(mild cognitive impairment,MCI)是介于正常老化和痴呆之间的过渡阶段,MCI患者是阿尔茨海默病(Alzheimer's disease,AD)的风险人群.本文介绍了国际上MCI诊断标准及其变化和修订,提出了理想的诊断模型.根据国内外研究,从认知和精神行为两个方面综述了MCI的神经心理损伤特征及其相应的诊断工具,简要回顾了现有针对MCI开展干预的各种方法.指出早期识别和干预研究需要从实验室小样本扩展到社区大样本老年人群,从横断研究扩展到纵向追踪,综合采用多种识别指标,并结合多种干预方法以达到最优效果.; Mild cognitive impairment (MCI) is an intermediate clinical state between normal aging and dementia, and MCI patients are the risk population for the development of Alzheimer's disease (AD). This article firstly introduced the international diagnosis criteria of MCI and its variations and modifications, and based on the previous findings, we proposed an ideal diagnosis model for MCI detection in which outmeasures included both patient's self-report, clinician's judgment and objective behavioral and neuropsychological tests as well as various biomarkers through advanced imaging techniques, cerebrospinal fluid analysis, or even urine endogenous formaldehyde analysis, both cross-sectional comparisons of an individual with the norms and longitudinal changes derived from multi-time point measurements were also involved. We reviewed the recent studies on the neuropsychological impairment characteristics of MCI and the corresponding measurement tools from both cognitive and neuropsychiatric aspects such as MMSE, MoCA, NPI and SC1D, and various cognitive intervention methods for MCI were also reviewed. Future research is needed to extend the findings from experimental small samples into community-based large population, as well as from the cross-sectional studies into longitudinal studies, and to adopt multi-detection markers and multi-intervention methods to achieve the optimal effects of early detection and intervention of MCI.
Keyword阿尔茨海默病 轻度认知障碍 早期识别 神经心理 干预
Subject Area医学心理学
Indexed ByCSCD ; SCI
Funding Organization国家自然科学基金(30770725,31070916) ; 国家科技支撑计划(2009BAI77B03) ; 中国科学院生命科学与生物技术局基础前沿专项(KSCX2-EW-J-8)资助项目
Citation statistics
Cited Times:6[CSCD]   [CSCD Record]
Document Type期刊论文
Corresponding Author李娟
Recommended Citation
GB/T 7714
李娟,喻婧,牛亚南. 轻度认知障碍的神经心理损伤特征及其早期识别与干预——预防和延缓阿尔茨海默病的发生[J]. 生物化学与生物物理进展,2012,39(8):804-810.
APA 李娟,喻婧,&牛亚南.(2012).轻度认知障碍的神经心理损伤特征及其早期识别与干预——预防和延缓阿尔茨海默病的发生.生物化学与生物物理进展,39(8),804-810.
MLA 李娟,et al."轻度认知障碍的神经心理损伤特征及其早期识别与干预——预防和延缓阿尔茨海默病的发生".生物化学与生物物理进展 39.8(2012):804-810.
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