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Alternative TitleEffects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress
刘丽琴1; 罗艳1; 张瑞睿1; 郭建友1
Source Publication中国中药杂志
Contribution Rank3
Other AbstractGingseng is commonly used in traditional Chinese medicine community for the treatment of depression-like disorders.Ginsenosides is considered to be the major active components of ginseng.Previous studies have demonstrated that ginsenosides produced antidepressant-like action in various mouse models of behavioral despair.The present study aimed to examine whether ginsenosides could affect the chronic unpredictable mild stress(CUMS)-induced depression in rats.The mechanism(s) underlying the antidepressant-like action was investigated by measuring serum corticosterone level,glucocorticoid receptor(GR),mineralocorticoid receptor(MR) and brain-derived neurotrophic factor(BDNF) mRNA levels in brain tissues.CUMS,being lasted for 6 weeks,caused depression-like behavior in rats,as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test.Whereas serum corticosterone level was significantly increased in rats exposed to CUMS,expressions of GR mRNA in hippocampus,and BDNF mRNA in hippocampus and frontal cortex,were decreased in CUMS-treated rats.Daily intragastric administration of ginsenosides(12.5,25,50 mg·kg-1) during the six weeks of CUMS significantly suppressed behavioral and biochemical changes induced by CUMS.However,there was no significant difference in MR mRNA level among groups.The results suggest that the antidepressant-like action of ginsenosides is likely mediated by modulating the function of hypothalamic-pituitary-adrenal axis and increasing the expression of BDNF in brain tissues.
Keyword抗抑郁 脑源性神经营养因子 慢性应激抑郁 下丘脑-垂体-肾上腺轴 人参皂苷
Subject Area变态心理学
Indexed ByCSCD
Funding Organization中国科学院心理研究所青年基金项目(08CX043004)
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Document Type期刊论文
Corresponding Author刘丽琴
Recommended Citation
GB/T 7714
刘丽琴,罗艳,张瑞睿,等. 人参皂苷对慢性应激抑郁模型大鼠行为学及HPA轴、BDNF的影响[J]. 中国中药杂志,2011,36(10):1342-1347.
APA 刘丽琴,罗艳,张瑞睿,&郭建友.(2011).人参皂苷对慢性应激抑郁模型大鼠行为学及HPA轴、BDNF的影响.中国中药杂志,36(10),1342-1347.
MLA 刘丽琴,et al."人参皂苷对慢性应激抑郁模型大鼠行为学及HPA轴、BDNF的影响".中国中药杂志 36.10(2011):1342-1347.
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