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首发精神分裂症患者的运动协调功能与前额叶白质及皮质脊髓束完整性
Alternative Titlemotor coordination and white matter integrity in prefrontal lobe and corticospinal tract in first-episode schizophrenia
程章1; 韩雪1; 杨磊1; 王煦1; 陈楚侨1; 于欣1; 洪楠1; 原岩波1
2012
Source Publication中国心理卫生杂志
ISSN1000-6729
Subtype期刊论文
Volume26Issue:8Pages:561-565
Contribution Rank3
Abstract目的:应用弥散张量成像(DTI)探讨首发精神分裂症患者神经系统软体征中的运动协调功能与前额叶白质及皮质脊髓束各向异性比值(FA)的关系。方法:纳入42例符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的首发精神分裂症患者和46例年龄、性别及受教育年限相匹配的健康对照。两组研究对象均用剑桥神经科检查(CNI)评定神经系统软体征,并接受头颅磁共振成像检查。用阳性与阴性症状量表(PANSS)评估患者组基线和半年后的临床症状。用感兴趣区测定的方法,分析患者组和对照组神经系统软体征中的运动协调领域分与前额叶白质及皮质脊髓束各层面(内囊、大脑脚、小脑中脚水平)FA值间的关系。结果:神经系统软体征中的运动协调领域分在患者组中与前额叶白质FA值呈正相关(r=0.35,P<0.05)。结论:本研究提示首发精神分裂症患者半年后阴性症状高分组、低分组及正常人群中,运动协调功能相关的脑区分别为前额叶、内囊和小脑中脚层面的皮质脊髓束,提示有必要进一步研究运动协调功能相关的脑区不同对患者预后的预测意义。; Objective: To investigate the correlation between motor coordination in neurological soft signs and fractional anisotropy (FA) value of prefrontal white matter and corticospinal tract in patients with first-episode schizophrenia. Methods: Forty two first-episode schizophrenic patients meeting the criteria of Diagnostic and Statis- tical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 46 normal controls matched on age, gender and education underwent neurological examination with excerpt of Cambridge Neurological Inventory (CNI) and diffu-sion tensor imaging (DTI). Symptom evaluation with PANSS was conducted at baseline and 6-month follow- up. Results: Motor coordination was positively correlated with FA value of prefrontal whiter matter in patients ( r = 0. 35, P 〈 0.05), while in controls it was positively correlated with FA value of corticospinal tract (r = 0. 34, P 〈 0.05). Motor coordination was positively correlated with FA value of prefrontal whiter matter (r = 0. 68, P 〈 0. 05) and negatively correlated with corticospinal tract (r = -0. 67, P 〈 0. 05) in patients with severer negative symptoms at 6-month follow-up, while it was positively correlated with FA value of internal capsule (r =0. 60, P 〈0. 05) in patients with milder negative symptoms. Conclusion: Motor coordination in neurological soft signs may be related to white matter integrity in prefrontal lobe, internal capsule and corticospinal cord in patients with severer negative symptoms at 6-month follow-up, patients with milder negative symptoms and normal controls, respectively. The differences of regions correlated with motor soft signs suggest different pathologic impairment occur in patients with different symptoms, and may predict negative symptoms at 6-month follow-up.
Keyword精神分裂症 弥散张量成像 神经系统软体征 运动协调
Subject Area变态心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization“十一五”国家科技支撑计划项目(2007BA117804),首都医学发展科研基金(2009-3030)
CSCD IDCSCD:4660255
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/14901
Collection中国科学院心理健康重点实验室
Corresponding Author洪楠
Affiliation1.北京大学精神卫生研究所卫生部精神卫生学重点实验室,北京 100191
2.北京大学人民医院放射科,北京 100035
3.中国科学院心理研究所心理健康重点实验室,北京 100101
Recommended Citation
GB/T 7714
程章,韩雪,杨磊,等. 首发精神分裂症患者的运动协调功能与前额叶白质及皮质脊髓束完整性[J]. 中国心理卫生杂志,2012,26(8):561-565.
APA 程章.,韩雪.,杨磊.,王煦.,陈楚侨.,...&原岩波.(2012).首发精神分裂症患者的运动协调功能与前额叶白质及皮质脊髓束完整性.中国心理卫生杂志,26(8),561-565.
MLA 程章,et al."首发精神分裂症患者的运动协调功能与前额叶白质及皮质脊髓束完整性".中国心理卫生杂志 26.8(2012):561-565.
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