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缬草素抗焦虑作用及其机制的初探
Alternative TitleEffects of valtrate on anxiety models in rats and its possible mechanisms
王延丽1; 刘勇1; 石晋丽1; 郭建友1; 郑虎占1; 翟玉静1
2011
Source Publication中国药理学通报
ISSN1001-1978
Subtype期刊论文
Volume27Issue:4Pages:501-504
Contribution Rank2
Abstract目的研究缬草素的抗焦虑作用,并分析其可能的作用机制。方法以大鼠高架十字迷宫实验和开场实验为动物模型,考察缬草素的抗焦虑活性;用酶联免疫吸附法(ELISA)测定大鼠血清皮质酮的水平。结果缬草素(10mg.kg-1)能增加大鼠在开臂内运动时间和次数百分率,并且提高大鼠在开场中央区的次数,在大鼠高架十字迷宫与开场模型上显示出抗焦虑作用;酶联免疫吸附法表明:缬草素能降低大鼠血清皮质酮水平。结论缬草素具有明显的抗焦虑作用,机制可能与调节下丘脑-垂体-肾上腺轴功能有关。
Other AbstractAim To study the anxiolytic effects of valtrate on anxiety models and investigate the related mechanisms.Methods The elevated plus-maze test(EPM) and open field were used as in vivo model,and the anxiolytic activities of valtrate were investigated.Then the corticosterone levels in the rat plasma were measured by enzyme-linked immunosorbent assay(ELISA).Result The valtrate(10 mg·kg-1,ig) exhibited the anxiolytic effect in rats by increasing the time and entry percentage into the open arms in the elevated plus maze and the number of central entries in the open filed.ELISA showed that valtrate significantly reduced the corticosterone level in the rat plasma.Conclusion The valtrate has anxiolytic activity in behavioral models that might be mediated via the function of hypothalamus-pituitary-adrenal axis(HPAA).
Keyword缬草素 焦虑 高架十字迷宫 开场 皮质酮 下丘脑-垂体-肾上腺轴
Subject Area医学心理学
URL查看原文
Indexed ByCSCD
Language中文
Funding Organization国家“重大新药创制”科技重大专项(No2009ZX09103-381) ; 中国科学院基础前沿性项目(NoKSCX2-EW-J-8)
CSCD IDCSCD:4185121
Citation statistics
Cited Times:7[CSCD]   [CSCD Record]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/15000
Collection中国科学院心理健康重点实验室
Corresponding Author刘勇
Affiliation1.北京中医药大学中药学院
2.中国科学院心理研究所中国科学院心理健康重点实验室
Recommended Citation
GB/T 7714
王延丽,刘勇,石晋丽,等. 缬草素抗焦虑作用及其机制的初探[J]. 中国药理学通报,2011,27(4):501-504.
APA 王延丽,刘勇,石晋丽,郭建友,郑虎占,&翟玉静.(2011).缬草素抗焦虑作用及其机制的初探.中国药理学通报,27(4),501-504.
MLA 王延丽,et al."缬草素抗焦虑作用及其机制的初探".中国药理学通报 27.4(2011):501-504.
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